Loading...
Publication
Alterações espetroscópicas e de perfusão cerebral na depressão major por ressonância magnética: revisão sistemática
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 945.09 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Introdução: A depressão major (DM) é caracterizada por alterações somáticas e cognitivas que afetam a capacidade de funcionamento do indivíduo. A sua etiologia não é ainda conhecida, considerando-se multifatorial, associada a suscetibilidade genética, stress e processos patológicos. Tem alta prevalência em indivíduos com doenças autoimunes e síndromes metabólicos e tem vindo a ser relacionada a alterações inflamatórias. Objetivos: A investigação procurou reunir estudos que demonstrem a utilidade da ressonância magnética (RM) para o diagnóstico da DM, nomeadamente pelas técnicas não invasivas de Arterial Spin Labeling (ASL) e Espectroscopia (ERM). Métodos: Foi efetuada uma pesquisa bibliográfica em quatro bases de dados (PubMed/MEDLINE, Cochrane Library, Web of Science e PsycINFO) através dos descritores Major Depression Disorder, Arterial Spin Labeling e MR Spectroscopy, até março de 2024. Foram estabelecidos os critérios de exclusão: estudos publicados antes de 2018; farmacológicos; de terapias electroconvulsiva ou estimulação magnética transcraniana; de outros tipos de depressão; que não façam quantificação da espetroscopia e Arterial Spin Labeling; cujo processo de publicação se encontre incompleto e não realizados em humanos; Quanto aos critérios de inclusão, admitiu-se: artigos que aplicam a técnicas Arterial Spin Labeling e Espetroscopia por Ressonância Magnética, em qualquer intensidade de B0; com qualquer protocolo; dirigidos a qualquer região da anatomia cerebral; disponíveis em texto integral em português, inglês ou espanhol que abordem os conceitos-chave. Resultados: Da pesquisa bibliográfica foram identificados 147 artigos, dos quais se eliminaram 35 duplicados, 13 foram excluídos com base nos dados fornecidos no resumo e após aplicados os critérios de exclusão analisaram-se 73 artigos, dos quais 25 foram incluídos no estudo. Conclusões: O Cerebral Blood Flow (CBF) mostrou alterações na maioria dos estudos, mas diferindo entre si. Quanto ao glutamato (Glu), vários estudos encontraram diminuição da concentração. A glutamina (Gln) foi encontrada aumentada no córtex occipital, no córtex cingulado anterior, no putámen e córtex occipital.
ABSTRACT Introduction: Major depression (MD) is characterized by somatic and cognitive changes that affect the individual's functioning capacity. The etiology of the disease is multifactorial but not fully understood, and has been associated with genetic susceptibility, stress, and pathological processes. It has a high prevalence in individuals with autoimmune diseases and metabolic syndromes and has been related to inflammatory alterations. Objectives: The research sought studies demonstrating the utility of magnetic resonance imaging for the diagnosis of MD, particularly through non-invasive techniques such as Arterial Spin Labeling and Spectroscopy. Methods: A bibliographic research was conducted in four databases (PubMed/MEDLINE, Cochrane Library, Web of Science, and PsycINFO) using the descriptors Major Depression Disorder, Arterial Spin Labeling, and MR Spectroscopy, up to March 2024. In advance, inclusion and exclusion criteria were established. Studies published before 2018, pharmacological studies, studies on electroconvulsive therapy or transcranial magnetic stimulation, studies on other types of depression, studies that do not quantify spectroscopy and ASL, studies with incomplete publication processes, and studies not conducted on humans were excluded. Articles applying Arterial Spin Labeling and spectroscopy techniques at any B0 intensity, using any protocol, in any region of the brain anatomy, are available in full text in Portuguese, English, or Spanish. Results: From the bibliographic research, 147 articles were identified, 35 duplicates were removed, and 13 were excluded based on the data provided in the abstract. After applying the exclusion criteria, 73 articles were analyzed, of which 25 were included in the study. Conclusions: Cerebral Blood Flow (CBF) showed alterations in most studies, but they differed from one another. Regarding Glutamate (Glu), several studies found a decrease in its concentration. Glutamine (Gln) was also found to be increased in the occipital cortex, anterior cingulate cortex, putamen, and occipital cortex.
ABSTRACT Introduction: Major depression (MD) is characterized by somatic and cognitive changes that affect the individual's functioning capacity. The etiology of the disease is multifactorial but not fully understood, and has been associated with genetic susceptibility, stress, and pathological processes. It has a high prevalence in individuals with autoimmune diseases and metabolic syndromes and has been related to inflammatory alterations. Objectives: The research sought studies demonstrating the utility of magnetic resonance imaging for the diagnosis of MD, particularly through non-invasive techniques such as Arterial Spin Labeling and Spectroscopy. Methods: A bibliographic research was conducted in four databases (PubMed/MEDLINE, Cochrane Library, Web of Science, and PsycINFO) using the descriptors Major Depression Disorder, Arterial Spin Labeling, and MR Spectroscopy, up to March 2024. In advance, inclusion and exclusion criteria were established. Studies published before 2018, pharmacological studies, studies on electroconvulsive therapy or transcranial magnetic stimulation, studies on other types of depression, studies that do not quantify spectroscopy and ASL, studies with incomplete publication processes, and studies not conducted on humans were excluded. Articles applying Arterial Spin Labeling and spectroscopy techniques at any B0 intensity, using any protocol, in any region of the brain anatomy, are available in full text in Portuguese, English, or Spanish. Results: From the bibliographic research, 147 articles were identified, 35 duplicates were removed, and 13 were excluded based on the data provided in the abstract. After applying the exclusion criteria, 73 articles were analyzed, of which 25 were included in the study. Conclusions: Cerebral Blood Flow (CBF) showed alterations in most studies, but they differed from one another. Regarding Glutamate (Glu), several studies found a decrease in its concentration. Glutamine (Gln) was also found to be increased in the occipital cortex, anterior cingulate cortex, putamen, and occipital cortex.
Description
Mestrado em Radiações Aplicadas às Tecnologias da Saúde
Keywords
Depressão major Ressonância magnética Espectroscopia Arterial spin labelling Major depression Magnetic resonance imaging Spectroscopy MRATeS
Citation
Abrantes NF. Alterações espetroscópicas e de perfusão cerebral na depressão major por ressonância magnética: revisão sistemática [dissertation]. Lisboa: Escola Superior de Tecnologia da Saúde de Lisboa/Instituto Politécnico de Lisboa; 2024.