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The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in modulating the risk of colorectal cancer in Portuguese persons

2007-06Journal article Open access
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dc.contributor.authorGuerreiro, Catarina Sousa
dc.contributor.authorCravo, Marília
dc.contributor.authorBrito, Miguel
dc.contributor.authorVidal, Pedro L.
dc.contributor.authorFidalgo, Paulo O.
dc.contributor.authorLeitão, Carlos Nobre
dc.date.accessioned2014-01-04T18:27:57Z
dc.date.available2014-01-04T18:27:57Z
dc.date.issued2007-06
dc.description.abstractBackground - Both genetic and environmental factors affect the risk of colorectal cancer (CRC). Objective - We aimed to examine the interaction between the D1822V polymorphism of the APC gene and dietary intake in persons with CRC. Design - Persons with CRC (n = 196) and 200 healthy volunteers, matched for age and sex in a case-control study, were evaluated with respect to nutritional status and lifestyle factors and for the D1822V polymorphism. Results - No significant differences were observed in energy and macronutrient intakes. Cases had significantly (P < 0.05) lower intakes of carotenes, vitamins C and E, folate, and calcium than did controls. Fiber intake was significantly (P = 0.004) lower in cases than in controls, whereas alcohol consumption was associated with a 2-fold risk of CRC. In addition, cases were significantly (P = 0.001) more likely than were controls to be sedentary. The homozygous variant for the APC gene (VV) was found in 4.6% of cases and in 3.5% of controls. Examination of the potential interactions between diet and genotype found that a high cholesterol intake was associated with a greater risk of colorectal cancer only in noncarriers (DD) of the D1822V APC allele (odds ratio: 1.66; 95% CI: 1.00, 2.76). In contrast, high fiber and calcium intakes were more markedly associated with a lower risk of CRC in patients carrying the polymorphic allele (DV/VV) (odds ratio: 0.50; 95% CI: 0.27, 0.94 for fiber; odds ratio: 0.51; 95% CI: 0.28, 0.93 for calcium) than in those without that allele. Conclusion - These results suggest a significant interaction between the D1822V polymorphism and the dietary intakes of cholesterol, calcium, and fiber for CRC risk.por
dc.identifier.citationGuerreiro CS, Cravo ML, Brito M, Vidal PM, Fidalgo PO, Leitão CN. The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in modulating the risk of colorectal cancer in Portuguese persons. Am J Clin Nutr. 2007;85(6):1592-7.por
dc.identifier.issn1938-3207
dc.identifier.urihttp://hdl.handle.net/10400.21/3074
dc.language.isoengpor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://ajcn.nutrition.org/content/85/6/1592.full.pdf+htmlpor
dc.subjectCalcium, Dietarypor
dc.subjectCase-control studiespor
dc.subjectColorectal neoplasmspor
dc.subjectDietpor
dc.subjectDietary fatspor
dc.subjectDietary fiberpor
dc.subjectEnergy intakepor
dc.subjectPolymorphism, Geneticpor
dc.subjectVitaminpor
dc.subjectPortugalpor
dc.titleThe D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in modulating the risk of colorectal cancer in Portuguese personspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1597por
oaire.citation.startPage1592por
oaire.citation.titleAmerican Journal of Clinical Nutritionpor
oaire.citation.volume85por
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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