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Serum zinc evolution in dysphagic patients that underwent endoscopic gastrostomy for long term enteral feeding

2017-03Journal article Restricted access
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dc.contributor.authorSantos, Carla Adriana
dc.contributor.authorFonseca, Jorge
dc.contributor.authorLopes, Maria Teresa Martins
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGuerreiro, António Sousa
dc.date.accessioned2017-08-17T12:19:17Z
dc.date.available2017-08-17T12:19:17Z
dc.date.issued2017-03
dc.description.abstractBackground and objectives - Patients undergoing endoscopic gastrostomy (PEG) present with protein-energy malnutrition (PEM) but little are known about zinc status. Our aim was to evaluate serum zinc, its relationship with serum proteins and with the nature of the underlying disorder, during the first 3 months of PEG feeding. Methods and study design - Prospective observational study during a 3-month period after gastrostomy. Data were collected at initial PEG procedure (T0), after 4 (T1) and 12 weeks (T3). Initial evaluation included: age, gender, a disorder causing dysphagia, Neurological Dysphagia (ND) or Head and Neck Cancer (HNC), NRS-2002, BMI, albumin, transferrin, zinc. At T1 and T3, a blood sample was collected for zinc, albumin, transferrin. Serum zinc evaluation was performed with ICP-AES - Inductively Coupled Plasma-Atomic Emission Spectroscopy. Patients were fed with homemade meals. Results - A total of 146 patients (89 males), 21-95 years were studied: HNC-56, ND-90 and low BMI in 78. Initial low zinc in 122; low albumin in 77, low transferrin in 94; low values for both proteins in 66. Regarding the serum protein evolution, their levels increase T0-T3, most patients reaching normal values. zinc has a slower evolution, most patients still displaying low zinc at T3. Significant differences between the 3 moments for zinc (p=0.011), albumin (p<0.0001) and transferrin (p=0.014). Conclusion - PEG patients are prone to PEM and zinc deficiency. Most patients present decreased zinc, suggesting that zinc deficiency is common in PEG candidates and is not corrected during 3 months of enteral feeding. Zinc deficiency should be expected and teams taking care of PEG patients should use zinc supplementation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos CA, Fonseca J, Lopes MT, Carolino E, Guerreiro AS. Serum zinc evolution in dysphagic patients that underwent endoscopic gastrostomy for long term enteral feeding. Asia Pac J Clin Nutr. 2017;26(2):227-33.pt_PT
dc.identifier.doi10.6133/apjcn.022016.03pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7327
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHEC Presspt_PT
dc.relation.publisherversionhttp://apjcn.nhri.org.tw/server/APJCN/26/2/227.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectDeglutition disorderspt_PT
dc.subjectEnteral nutritionpt_PT
dc.subjectFemalept_PT
dc.subjectHead and neck neoplasmspt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle agedpt_PT
dc.subjectNervous system diseasespt_PT
dc.subjectProspective studiespt_PT
dc.subjectProtein-energy malnutritionpt_PT
dc.subjectSerum albuminpt_PT
dc.subjectTransferrinpt_PT
dc.subjectZincpt_PT
dc.subjectGastrostomypt_PT
dc.subjectLaparoscopypt_PT
dc.titleSerum zinc evolution in dysphagic patients that underwent endoscopic gastrostomy for long term enteral feedingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage233pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage227pt_PT
oaire.citation.titleAsia Pacific Journal of Clinical Nutritionpt_PT
oaire.citation.volume26pt_PT
person.familyNameCarolino
person.givenNameElisabete
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.orcid0000-0003-4165-7052
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id25821697000
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication.latestForDiscovery77930d39-ed34-44dc-a4a6-9bf833e5e688

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