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Occupational exposure to cytotoxic drugs: the importance of surface cleaning to prevent or minimise exposure

2018-08Journal article Open access
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dc.contributor.authorViegas, Susana
dc.contributor.authorOliveira, Ana Cebola de
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorPádua, Mário
dc.date.accessioned2018-10-19T16:07:04Z
dc.date.available2018-10-19T16:07:04Z
dc.date.issued2018-08
dc.description.abstractHealthcare workers who prepare or administer cytotoxic agents run the risk of exposure, and the risks for health are real even at doses lower than those applied in cancer patients, because, in theory, no dose is safe. The most common and problematic route of exposure is through the skin, especially as work surfaces can remain contaminated even after cleaning. This pilot study aimed to demonstrate the importance of having an effective surface decontamination protocol by determining surface contamination with cyclophosphamide, 5-fluorouracil, and paclitaxel as the most common cytotoxic drugs in an oncology day service. Samples were collected before and after drug handling and analysed with high performance liquid chromatography with diode array detection (HPLC-DAD). Of the 29 samples collected before drug handling 23 were contaminated, five of which with more than one drug. Of the 30 samples collected after drug handling 25 were contaminated, eight of which with more than one drug. The two time points did not significantly differ, which evidences a widespread contamination and ineffective cleaning. This calls for revising the cleaning protocol and handling procedure to place contamination under control as much as possible.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViegas S, Oliveira AC, Carolino E, Pádua M. Occupational exposure to cytotoxic drugs: the importance of surface cleaning to prevent or minimise exposure. Arh Hig Rada Toksikol. 2018;69(3):238-49.pt_PT
dc.identifier.doi10.2478/aiht-2018-69-3137pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/8950
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDe Gruyterpt_PT
dc.relation.publisherversionhttps://www.degruyter.com/view/j/aiht.2018.69.issue-3/aiht-2018-69-3137/aiht-2018-69-3137.xmlpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subject5-fluoroacilpt_PT
dc.subjectContamination controlpt_PT
dc.subjectCyclophosphamidept_PT
dc.subjectHPLC-DADpt_PT
dc.subjectOncology day servicept_PT
dc.subjectPaclitaxelpt_PT
dc.titleOccupational exposure to cytotoxic drugs: the importance of surface cleaning to prevent or minimise exposurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage249pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage238pt_PT
oaire.citation.titleArchives of Industrial Hygiene and Toxicologypt_PT
oaire.citation.volume69pt_PT
person.familyNameViegas
person.familyNameCarolino
person.givenNameSusana
person.givenNameElisabete
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-4165-7052
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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