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Role of macronutrients and micronutrients in DNA damage: results from a food frequency questionnaire

2017-02Journal article Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGomes, Manuel C.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2017-05-16T11:45:21Z
dc.date.available2017-05-16T11:45:21Z
dc.date.issued2017-02
dc.description.abstractThe links between diet and genomic instability have been under investigation for several decades, and evidence suggests a significant causal or preventive role for various dietary factors. This study investigates the influence of macronutrients (calories, protein, and glucides) and micronutrients, such as vitamins and minerals, as assessed by a food frequency questionnaire, on genotoxicity biomarkers measured by cytokinesis-blocked micronucleus assay and comet assay. The results found significant positive and negative correlations. Micronucleus frequency tends to increase with higher intake of caffeine, calcium, magnesium, zinc, and protein (P < .05, Spearman correlation). Calorie and omega-6 intakes are negatively correlated with DNA damage measured by the comet assay. These results are somewhat controversial because some of the correlations found are contrary to dominant views in the literature; however, we suggest that unraveling the association between diet and genetic instability requires a much better understanding of the modulating role of macronutrients and micronutrients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLadeira C, Carolino E, Gomes MC, Brito M. Role of macronutrients and micronutrients in DNA damage: results from a food frequency questionnaire. Nutr Metab Insights. 2017;10:1-10.pt_PT
dc.identifier.doi10.1177/1178638816684666pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7012
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Publicationspt_PT
dc.relation.publisherversionhttp://insights.sagepub.com/role-of-macronutrients-and-micronutrients-in-dna-damage-results-from-a-article-a6125pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/pt_PT
dc.subjectMacronutrientspt_PT
dc.subjectMicronutrientspt_PT
dc.subjectFood frequency questionnairept_PT
dc.subjectGenetic instabilitypt_PT
dc.subjectCBMN assaypt_PT
dc.subjectComet assaypt_PT
dc.titleRole of macronutrients and micronutrients in DNA damage: results from a food frequency questionnairept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNutrition and Metabolic Insightspt_PT
oaire.citation.volume10pt_PT
person.familyNameLadeira
person.familyNameCarolino
person.familyNameBrito
person.givenNameCarina
person.givenNameElisabete
person.givenNameMiguel
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridF-1012-2015
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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