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Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities

2019-01Journal article Restricted access
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dc.contributor.authorZaidi, Hicham
dc.contributor.authorOuchemoukh, Salim
dc.contributor.authorAmessis-Ouchemoukh, Nadia
dc.contributor.authorDEBBACHE-BENAIDA, NADJET
dc.contributor.authorPacheco, Rita
dc.contributor.authorSerralheiro, Maria Luisa
dc.contributor.authorAraujo, Maria Eduarda
dc.date.accessioned2019-02-08T14:37:06Z
dc.date.available2019-02-08T14:37:06Z
dc.date.issued2019-01
dc.description.abstractIntroduction: Honey is used in various cultures as a traditional medicine and folkloric treatment. The aim of this study was to determine the antioxidant and the anti-inflammatory activities of 31 Algerian honeys and acetylcholinesterase (AChE) and alpha-glucosidase inhibitory activities of phenolic compounds extracts of these honeys. Methods: The anti-inflammatory activity of honey was evaluated by the method of inhibition of BSA (Bovin Serum Albumin) heat-induced denaturation. The inhibition of AChE and alpha-glucosidase by the honey extracts was evaluated by in-vitro methods. Results: The highest percentage of inhibition (85.33%) of BSA denaturation was obtained with polyfloral honey (H27). Radical scavenging activity of honey samples against 1,1-diphenyl-2-picrilhydrazyl (DPPH), and 2,2'-azinobis(-3) -ethylbenzothiazoline-6-sulfonic acid (ABTS) varied from 4.41 to 83.93% and from 2.52 to 63.24%, respectively. AChE inhibitory activity is one target to prevent neurodegenerative damage in Alzheimer's disease. AChE inhibition recorded values from 20.69 to 76.04%. alpha-glucosidase inhibitors such as acarbose is preconized for the control of hyperglycemia and prevent diabetes damages. Honey extracts demonstrated a significant inhibitory effect on alpha-glucosidase activity. Moreover, the effect of Fabacece honey (H19) (IC50 = 52.20 mu g/mL) was found to be more potent than acarbose (IC50 = 204.27 mu g/mL). Correlations were observed between antioxidants and anti-inflammatory activities, AChE and alpha-glucosidase inhibitions with total phenolic compounds and flavonoids content in honey samples. Conclusion: This study showed that honey could be exploited as a potential antioxidant and anti-inflammatory agent within therapeutic medicine.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZAIDI, Hicham; [et al] – Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities. European Journal of Integrative Medicine. ISSN 1876-3820. Vol. 25, (2019), pp. 77-84pt_PT
dc.identifier.doi10.1016/j.eujim.2018.11.008pt_PT
dc.identifier.issn1876-3820
dc.identifier.issn1876-3839
dc.identifier.urihttp://hdl.handle.net/10400.21/9474
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationF00620130023 - Ministry of Higher Education and Scientific Research of Algeriapt_PT
dc.relation.publisherversionhttps://reader.elsevier.com/reader/sd/pii/S1876382018306759?token=BA4692F998D9F49E2DED8F7F044B7603728BA46CE9F21798B1F46A518C30FE3741CE5810011780FC9B5B0FFA304E61EDpt_PT
dc.subjectAlgerian honeyspt_PT
dc.subjectAnti-inflammatory activitypt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectAcetylcholinesterase inhibitionpt_PT
dc.subjectAlpha-Glucosidase inhibitionpt_PT
dc.subjectPhenolic compoundspt_PT
dc.titleBiological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activitiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage84pt_PT
oaire.citation.startPage77pt_PT
oaire.citation.titleEuropean Journal of Integrative Medicinept_PT
oaire.citation.volume25pt_PT
person.familyNameDEBBACHE-BENAIDA
person.familyNamePacheco
person.familyNameSerralheiro
person.familyNameAraujo
person.givenNameNADJET
person.givenNameRita
person.givenNameMaria Luisa
person.givenNameMaria Eduarda
person.identifier1022927
person.identifier.ciencia-id9F13-D310-B5A3
person.identifier.orcid0000-0003-1561-7305
person.identifier.orcid0000-0001-5192-3006
person.identifier.orcid0000-0001-7541-9613
person.identifier.orcid0000-0002-9876-9015
person.identifier.ridC-3062-2012
person.identifier.ridE-3407-2012
person.identifier.ridE-6528-2012
person.identifier.scopus-author-id8853708300
person.identifier.scopus-author-id6602688573
person.identifier.scopus-author-id7202962614
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8f0da1de-6e78-4f94-a98a-46f126fea243
relation.isAuthorOfPublicationd6907c0a-3f8f-431c-acf2-0b257692f0d4
relation.isAuthorOfPublication88895442-2a46-4878-a83f-435152a9cbb4
relation.isAuthorOfPublicationca23020f-df9d-4134-86d2-71dac7a97c1e
relation.isAuthorOfPublication.latestForDiscovery88895442-2a46-4878-a83f-435152a9cbb4

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