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Characterization of a novel 3D-polymeric scaffold as a co-delivery system

2020-01Conference object Open access
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dc.contributor.authorZegre, Miguel
dc.contributor.authorSilveira, M.
dc.contributor.authorAnjos, I.
dc.contributor.authorRibeiro, I. A.
dc.contributor.authorSantos, C.
dc.contributor.authorCaetano, Liliana Aranha
dc.contributor.authorGonçalves, L.
dc.contributor.authorBettercourt, A.
dc.date.accessioned2021-03-04T19:10:09Z
dc.date.available2021-03-04T19:10:09Z
dc.date.issued2020-01
dc.description.abstractOsteomyelitis is an inflammation of the bone caused by infection, leading to necrosis and tissue destruction. It can cause persistent morbidity and become a chronic disease, being one of the infectious diseases most difficult to manage. Staphylococcus aureus is the most usual causative pathogen in osteomyelitis, and bacterial infections are often complicated by concomitant fungal infections, Candida sp. being the most common. Co-encapsulation of drugs provides a convenient means for the administration of multiple drugs directed at commonly associated diseases. Three-dimensional scaffolds have become a crucial element of bone tissue engineering and regenerative medicine, are designed to provide an ideal environment for bone formation. Thus, this work aims to develop a new local drug-delivery system for the modulation of polymicrobial activity in bone infections, through the co-delivery of minocycline and voriconazole to the local site of infection, while fostering bone repair.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZegre M, Silveira M, Anjos I, Ribeiro I, Santos C, Caetano LA, et al. Characterization of a novel 3D-polymeric scaffold as a co-delivery system. In: XIII Spanish-Portuguese Conference on Controlled Drug Delivery 2020, Santiago de Compostela (Spain), January 22-24, 2020. p. 96.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13040
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationFCT_UID/DTP/04138/2013pt_PT
dc.relation.publisherversionhttps://www.splc-crs.org/meeting-2020/sites/default/files/docs/abstract_book_2020.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOsteomyelitispt_PT
dc.subject3D-polymeric scaffoldpt_PT
dc.subjectStaphylococcus aureuspt_PT
dc.subjectRegenerative medicinept_PT
dc.titleCharacterization of a novel 3D-polymeric scaffold as a co-delivery systempt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceSantiago de Compostelapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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