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Advisor(s)
Abstract(s)
Multidrug-resistant bacteria pose a major threat to effective antibiotics and alternatives to fight multidrug-resistant pathogens are needed. We synthetized molybdenum oxide (MoO3) nanoparticles (NP) and determined their antibacterial activity against 39 isolates: (i) eight Staphylococcus aureus, including representatives of methicillin-resistant S. aureus epidemic clones; (ii) six enterococci, including vancomycin-resistant isolates; and (iii) 25 Gram-negative isolates (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter cloacae), including extended spectrum beta-lactamases and carbapenemases producers. All isolates showed a MoO3 NP MIC of 700–800 mg l−1. MoO3 NP produced a clear inhibition zone for S. aureus and all Gram-negative isolates at concentrations ≥25 mg ml−1 and ≥50 mg ml−1 for enterococci. When the NP solutions were adjusted to pH ~7, the biocidal activity was completely abolished. MoO3 NP create an acidic pH and show a universal antimicrobial activity against susceptible and resistant isolates belonging to the most relevant bacterial species responsible for hospital-acquired infections.
Description
Keywords
Molybdenum oxide Nanoparticles Multidrug-resistant bacteria Bactericidal efficacy Nanopartículas Bactérias multirresistentes
Citation
LOPES, E.; [et al] – Bactericidal efficacy of molybdenum oxide nanoparticles against antimicrobial-resistant pathogens. Journal of Medical Microbiology. ISSN 0022-2615. Vol. 67, N.º 8 (2018), pp. 1042-1046
Publisher
Microbiology Society