Repository logo
 
Publication

Bactericidal efficacy of molybdenum oxide nanoparticles against antimicrobial-resistant pathogens

2018-08Journal article Restricted access
Simple item page
dc.contributor.authorLopes, Elizeth
dc.contributor.authorPiçarra, S.
dc.contributor.authorAlmeida, Pedro L.
dc.contributor.authorLencastre, H. de
dc.contributor.authorAires-de-Sousa, Marta
dc.date.accessioned2019-01-29T10:40:35Z
dc.date.available2019-01-29T10:40:35Z
dc.date.issued2018-08
dc.description.abstractMultidrug-resistant bacteria pose a major threat to effective antibiotics and alternatives to fight multidrug-resistant pathogens are needed. We synthetized molybdenum oxide (MoO3) nanoparticles (NP) and determined their antibacterial activity against 39 isolates: (i) eight Staphylococcus aureus, including representatives of methicillin-resistant S. aureus epidemic clones; (ii) six enterococci, including vancomycin-resistant isolates; and (iii) 25 Gram-negative isolates (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter cloacae), including extended spectrum beta-lactamases and carbapenemases producers. All isolates showed a MoO3 NP MIC of 700–800 mg l−1. MoO3 NP produced a clear inhibition zone for S. aureus and all Gram-negative isolates at concentrations ≥25 mg ml−1 and ≥50 mg ml−1 for enterococci. When the NP solutions were adjusted to pH ~7, the biocidal activity was completely abolished. MoO3 NP create an acidic pH and show a universal antimicrobial activity against susceptible and resistant isolates belonging to the most relevant bacterial species responsible for hospital-acquired infections.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLOPES, E.; [et al] – Bactericidal efficacy of molybdenum oxide nanoparticles against antimicrobial-resistant pathogens. Journal of Medical Microbiology. ISSN 0022-2615. Vol. 67, N.º 8 (2018), pp. 1042-1046pt_PT
dc.identifier.doi10.1099/jmm.0.000789pt_PT
dc.identifier.issn0022-2615
dc.identifier.urihttp://hdl.handle.net/10400.21/9371
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMicrobiology Societypt_PT
dc.relationPTDC/FIS/NAN/0117/2014pt_PT
dc.relationLISBOA-01-0145-FEDER-007660 - Microbiologia Molecular, Estrutural e Celularpt_PT
dc.relation03/BI/2017 - FCTpt_PT
dc.subjectMolybdenum oxidept_PT
dc.subjectNanoparticlespt_PT
dc.subjectMultidrug-resistant bacteriapt_PT
dc.subjectBactericidal efficacypt_PT
dc.subjectNanopartículaspt_PT
dc.subjectBactérias multirresistentespt_PT
dc.titleBactericidal efficacy of molybdenum oxide nanoparticles against antimicrobial-resistant pathogenspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-EPI%2F0842%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FCTM%2F50025%2F2013/PT
oaire.citation.endPage1046pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1042pt_PT
oaire.citation.titleJournal of Medical Microbiologypt_PT
oaire.citation.volume67pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
person.familyNameLopes
person.familyNameMarques de Almeida
person.familyNameAires-de-Sousa
person.givenNameElizeth
person.givenNamePedro
person.givenNameMarta
person.identifier.ciencia-idE51A-817A-39AE
person.identifier.ciencia-id0218-71B2-2DE0
person.identifier.ciencia-idCC11-681F-CED1
person.identifier.orcid0000-0002-9837-5155
person.identifier.orcid0000-0001-7356-8455
person.identifier.orcid0000-0001-5036-2446
person.identifier.ridB-4356-2009
person.identifier.scopus-author-id57190384213
person.identifier.scopus-author-id6603316273
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication12cae01b-7861-4c2d-8d37-677271705baa
relation.isAuthorOfPublication429b6d71-328e-42b3-8151-15493de249b8
relation.isAuthorOfPublicationf3537080-62cc-4b0d-9e47-1a7ea3df7b63
relation.isAuthorOfPublication.latestForDiscoveryf3537080-62cc-4b0d-9e47-1a7ea3df7b63
relation.isProjectOfPublicatione19c452a-0b77-4fdf-a79b-e1e0e606eac2
relation.isProjectOfPublicatione7fba2ab-23e9-40ca-a6de-695e974393e6
relation.isProjectOfPublication.latestForDiscoverye7fba2ab-23e9-40ca-a6de-695e974393e6

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2018 J Med Microbiol 67 1042–1046.pdf
Size:
1.5 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ISEL - Física - Artigos