Repository logo
 
Publication

Hospital surfaces contamination with antineoplastic drugs: influence of cleaning procedures

2016-06Conference object Open access
Simple item page
dc.contributor.authorOliveira, Ana Cebola
dc.contributor.authorPádua, Mário
dc.contributor.authorViegas, Susana
dc.date.accessioned2016-07-01T09:05:48Z
dc.date.available2016-07-01T09:05:48Z
dc.date.issued2016-06
dc.description.abstractIntroduction: The raising frequency of cancer diseases is leading to a widespread application of antineoplastic drugs, thus increasing the probability of workplace surfaces contamination. Most of these drugs are classified by the International Agency for Research on Cancer as known or suspected human carcinogens. Skin absorption is the main route for antineoplastic drugs exposure in occupational settings, therefore cleaning protocols have paramount influence in surfaces contamination and, consequently, in exposure. The aim of this study was to assess surfaces contamination in a Portuguese chemotherapy unit before and during drug administration, in both preparation and administration facilities. Methods: Samples were collected by wipe-sampling from potentially contaminated surfaces selected by previous protocol observation. Samples were analyzed by HPLCDAD. Cyclophosphamide (CP), 5-fluorouracil (5FU), and paclitaxel (PTX) were used as surrogate markers for surfaces contamination for all cytotoxic drugs. Results: From the 34 samples collected before any preparation and administration activities, 41.2% were contaminated with 5-FU (4.0-84.7 ng/cm2) and 23.5% of the samples were contaminated with CP (19.8-139.6 μg/cm2). Only 2 samples presented contamination by PTX (5.9%) with a maximum value of 3.7 ng/cm2. Of the 37 samples collected during preparation and administration of antineoplastic drugs, 48.7% were contaminated with 5-FU (1.9-88.7 ng/cm2) and 24.3% with CP (12.0-93.9 μg/cm2). None of the samples showed contamination with PTX. Discussion: Data showed differences in contamination levels before and after the handling of antineoplastic drugs in preparation and in administration settings. These results point out the importance of cleaning procedures. This is well in accordance to previous studies that showed how the type of cleaning procedures and products used can be determinant for surfaces decontamination.pt_PT
dc.identifier.citationOliveira AC, Pádua M, Viegas S. Hospital surfaces contamination with antineoplastic drugs: influence of cleaning procedures. In: ICOETOX2016 – International Conference on Occupational & Environmental Toxicology, Porto, 21-23 June 2016.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/6279
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttp://www.icoetox2016.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectOccupational exposurept_PT
dc.subjectContaminationpt_PT
dc.subjectHospitalpt_PT
dc.subjectAntineoplastic drugpt_PT
dc.subjectChemotherapypt_PT
dc.subjectPortugalpt_PT
dc.titleHospital surfaces contamination with antineoplastic drugs: influence of cleaning procedurespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopt_PT
person.familyNameViegas
person.givenNameSusana
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

Files

Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
Hospital surfaces contamination with antineoplastic drugs_influence of cleaning procedures2.pdf
Size:
89.15 KB
Format:
Adobe Portable Document Format
Description:
Abstract
Download
No Thumbnail Available
Name:
Hospital surfaces contamination with antineoplastic drugs_influence of cleaning procedures1.pdf
Size:
1.99 MB
Format:
Adobe Portable Document Format
Description:
Slides presentation
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Comunicações