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Health related quality of life in patients with refractory chronic heart failure undergoing cardiac resynchronization: type of therapeutic response

2011-04Journal article Open access
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dc.contributor.authorNave Leal, Elisabete
dc.contributor.authorPais-Ribeiro, José Luís
dc.contributor.authorOliveira, Mário
dc.contributor.authorNogueira da Silva, M.
dc.contributor.authorFeliciano, Joana
dc.contributor.authorSoares, Rui
dc.contributor.authorSantos, Sofia
dc.contributor.authorAlves, Sandra
dc.contributor.authorFerreira, Rui
dc.date.accessioned2011-12-06T11:53:50Z
dc.date.available2011-12-06T11:53:50Z
dc.date.issued2011-04
dc.description.abstractThe benefits of cardiac resynchronization therapy (CRT) in the health-related quality of life (HRQL) are largely demonstrated in selected patients with severe congestive heart failure (CHF). However, the differences between responders and non-responders, with regard to the effect of CRT in the various dimensions that constitute HRQL are still a matter of discussion. Objective: To evaluate the impact of CRT on the HRQL of patients with CHF refractory to optimal pharmacological therapy, within 6 months after CRT. Methods: 43 patients, submitted to successful implantation of CRT, were evaluated in hospital just before intervention and in the outpatient clinic within 6 months after CRT. HRQL was analyzed based on the Kansas City Cardiomyopathy Questionnaire (KCCQ). Patients were classified as super-responders (ejection fraction of left ventricle - LVEF - ≥45% post-CRT), n=15, responders (sustained improvement in functional class and LVEF increased by 15%), n=19, and non-responders (no clinical or LVEF improvement), n=9. Results: In the group of super-responders, CRT was associated with an improvement in HRQL for the various fields and sums assessed (ρ<0.05); in responders, CRT has been associated with an improvement of HRQL in the various fields and sums, except in the self-efficacy dimension (ρ<0.05); in non-responders, CRT was not associated with improvement of HRQL. Conclusion: In a population with severe CHF undergoing CRT, the patients with clinical and echocardiographic positive response, obtained a favorable impact in all dimensions of HRQL, while the group without response to CRT showed no improvement. These data reinforces the importance of HRQL as a multidimensional tool for assessment of benefits in clinical practice.por
dc.identifier.citationNave Leal E, Pais-Ribeiro JL, Oliveira M, Nogueira da Silva M, Feliciano J, Soares R, et al. Health related quality of life in patients with refractory chronic heart failure undergoing cardiac resynchronization: type of therapeutic response. Rom J Intern Med. 2011;(2).por
dc.identifier.urihttp://hdl.handle.net/10400.21/807
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherRevista Societatii de Medicina Internapor
dc.relation.publisherversionhttp://www.medicina-interna.ro/articol.php?articol=648&lang=ropor
dc.subjectCardiologiapor
dc.subjectReabilitaçãopor
dc.subjectCardiomiopatiapor
dc.subjectInsuficiência cardíaca congestivapor
dc.subjectQualidade de vidapor
dc.titleHealth related quality of life in patients with refractory chronic heart failure undergoing cardiac resynchronization: type of therapeutic responsepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleRomanian Journal of Internal Medicinepor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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