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Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding

2017-08Journal article Restricted access
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dc.contributor.authorSaha, Manideepa
dc.contributor.authorVyas, Komal M.
dc.contributor.authorMartins, Luisa
dc.contributor.authorMartins, Nuno M. R.
dc.contributor.authorPombeiro, Armando
dc.contributor.authorMobin, Shaikh M.
dc.contributor.authorBhattacherjee, D.
dc.contributor.authorBhabak, Krishna P.
dc.contributor.authorMukhopadhyay, Suman
dc.date.accessioned2017-11-20T12:41:10Z
dc.date.available2017-11-20T12:41:10Z
dc.date.issued2017-08
dc.description.abstractThree new coordination complexes [Cu-2(phen)(2)(ptz)(4)] (1), [Cu(phen)(pmtz)(2)] (2) and [Cu(phen)(pytz)(2)] (3) (ptz = 5-phenyltetrazolate, pmtz = 5-(2-pyrimidyl)tetrazolate and pytz = 5-(2-pyridyl)tetrazolate) have been synthesized using metal mediated [2+3] cycloaddition reaction between copper bound azide polymer and different organonitriles. All complexes have been structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Complex 1 shows a dinuclear structure via bridging ptz, while 2 and 3 reveal mononuclear structures. These complexes were explored as homogeneous catalysts for the selective peroxidative (with tBuOOH) oxidation of cyclohexane to cyclohexanol and cyclohexanone (KA oil) under very mild and green (solvent-and additive-free) conditions using microwave irradiation. The catecholase-like activity of the synthesized Cu(II) complexes was investigated by employing 3,5-di-tert-butylcatechol (DTBC) as a convenient model substrate, which showed first order kinetics with respect to the substrate in the oxidation of 3,5-di-tert-butyl catechol (DTBC) to 3,5-di-tertbutyl benzoquinone (DTBQ). Further, the interaction of synthesized Cu(II)-tetrazolato complexes with bovine serum albumin (BSA) was studied experimentally as well as through molecular docking to obtain detailed binding information of the Cu(II) complexes with BSA, which revealed higher binding of complex 1 than 2 and 3pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSAHA, Manideepa [et al] - Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding. Polyhedron. ISSN 0277-5387. Vol.132 (2017), pp. 53-63pt_PT
dc.identifier.doi10.1016/j.poly.2017.04.016pt_PT
dc.identifier.issn0277-5387
dc.identifier.urihttp://hdl.handle.net/10400.21/7561
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPergamon-Elsevier Sciencept_PT
dc.relation.publisherversionhttps://ac.els-cdn.com/S0277538717302851/1-s2.0-S0277538717302851-main.pdf?_tid=c539a2d8-cba3-11e7-b45b-00000aab0f02&acdnat=1510929171_61c6190fb7aea010b1f96678ad7cd5dbpt_PT
dc.subjectCu(II)-tetrazolato complexespt_PT
dc.subjectCatecholase-like activitypt_PT
dc.subjectKA oilpt_PT
dc.subjectGreen catalystpt_PT
dc.subjectProtein bindingpt_PT
dc.titleCopper(II) tetrazolato complexes: Role in oxidation catalysis and protein bindingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQEQ-ERQ%2F1648%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQEQ-QIN%2F3967%2F2014/PT
oaire.citation.endPage63pt_PT
oaire.citation.startPage53pt_PT
oaire.citation.titlePolyhedronpt_PT
oaire.citation.volume132pt_PT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameSaha
person.familyNameMartins
person.familyNamePombeiro
person.givenNameManideepa
person.givenNameLuisa
person.givenNameArmando
person.identifier637885
person.identifier.ciencia-idE218-E297-A4EA
person.identifier.ciencia-id8311-38FA-CEFB
person.identifier.orcid0000-0002-5522-4357
person.identifier.orcid0000-0002-5403-9352
person.identifier.orcid0000-0001-8323-888X
person.identifier.ridG-6210-2011
person.identifier.ridI-5945-2012
person.identifier.scopus-author-id8650947800
person.identifier.scopus-author-id7006067269
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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