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Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review

2022-12Journal article Open access
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dc.contributor.authorMatos, Pedro Henrique de
dc.contributor.authorSilva, Thalita Prates da
dc.contributor.authorMansano, Amanda Benites
dc.contributor.authorGancedo, Naiara Cássia
dc.contributor.authorTonin, Fernanda
dc.contributor.authorPelloso, Fernando Castilho
dc.contributor.authorPetruco, Marcus Vinicius
dc.contributor.authorMelo, Eduardo Borges de
dc.contributor.authorFernandez-Llimos, Fernando
dc.contributor.authorSanches, Andreia Cristina Conegero
dc.contributor.authorMello, João Carlos Palazzo de
dc.contributor.authorChierrito, Danielly
dc.contributor.authorAraújo, Daniela Cristina de Medeiros
dc.date.accessioned2022-11-08T17:10:42Z
dc.date.available2022-11-08T17:10:42Z
dc.date.issued2022-12
dc.description.abstractObjective and design: The current study aimed to summarize the evidence of compounds contained in plant species with the ability to block the angiotensin-converting enzyme 2 (ACE-II), through a scoping review. Methods: PubMed and Scopus electronic databases were used for the systematic search and a manual search was performed RESULTS: Studies included were characterized as in silico. Among the 200 studies retrieved, 139 studies were listed after the exclusion of duplicates, and 74 were included for the full read. Among them, 32 studies were considered eligible for the qualitative synthesis. The most evaluated class of secondary metabolites was flavonoids with quercetin and curcumin as most actives substances and terpenes (isothymol, limonin, curcumenol, anabsinthin, and artemisinin). Other classes also evaluated were alkaloid, saponin, quinone, substances found in essential oils, and primary metabolites such as the aminoacid L-tyrosine and the lipidic compound 2-monolinolenin. Conclusion: This review suggests the most active substance from each class of metabolites, which presented the strongest affinity to the ACE-II receptor, which contributes as a basis for choosing compounds and directing further experimental and clinical investigation on the applications these compounds in biotechnological and health processes as in COVID-19 pandemic.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMatos PH, Silva TP, Mansano AB, Gancedo NC, Tonin FS, Castilho Pelloso F, et al. Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review. Inflamm Res. 2022;71(12):1489-500.pt_PT
dc.identifier.doi10.1007/s00011-022-01642-7pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15080
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00011-022-01642-7pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectACE-IIpt_PT
dc.subjectCoronaviruspt_PT
dc.subjectSecondary metabolitept_PT
dc.subjectTreatmentpt_PT
dc.titleBioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1500pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1489pt_PT
oaire.citation.titleInflammation Researchpt_PT
oaire.citation.volume71pt_PT
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

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