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Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production

2010-08Journal article Open access
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dc.contributor.authorViegas, Susana
dc.contributor.authorLadeira, Carina
dc.contributor.authorNunes, Carla
dc.contributor.authorMalta-Vacas, Joana
dc.contributor.authorGomes, Mário
dc.contributor.authorBrito, Miguel
dc.contributor.authorMendonça, Paula
dc.contributor.authorPrista, João
dc.date.accessioned2014-01-03T22:17:05Z
dc.date.available2014-01-03T22:17:05Z
dc.date.issued2010-08
dc.description.abstractBackground - According to the Report on Carcinogens, formaldehyde ranks 25th in the overall U.S. chemical production, with more than 5 million tons produced each year. Given its economic importance and widespread use, many people are exposed to formaldehyde environmentally and/or occupationally. Presently, the International Agency for Research on Cancer classifies formaldehyde as carcinogenic to humans (Group 1), based on sufficient evidence in humans and in experimental animals. Manyfold in vitro studies clearly indicated that formaldehyde can induce genotoxic effects in proliferating cultured mammalian cells. Furthermore, some in vivo studies have found changes in epithelial cells and in peripheral blood lymphocytes related to formaldehyde exposure. Methods - A study was carried out in Portugal, using 80 workers occupationally exposed to formaldehyde vapours: 30 workers from formaldehyde and formaldehyde-based resins production factory and 50 from 10 pathology and anatomy laboratories. A control group of 85 non-exposed subjects was considered. Exposure assessment was performed by applying simultaneously two techniques of air monitoring: NIOSH Method 2541 and Photo Ionization Detection equipment with simultaneously video recording. Evaluation of genotoxic effects was performed by application of micronucleus test in exfoliated epithelial cells from buccal mucosa and peripheral blood lymphocytes. Results - Time-weighted average concentrations not exceeded the reference value (0.75 ppm) in the two occupational settings studied. Ceiling concentrations, on the other hand, were higher than reference value (0.3 ppm) in both. The frequency of micronucleus in peripheral blood lymphocytes and in epithelial cells was significantly higher in both exposed groups than in the control group (p < 0.001). Moreover, the frequency of micronucleus in peripheral blood lymphocytes was significantly higher in the laboratories group than in the factory workers (p < 0.05). A moderate positive correlation was found between duration of occupational exposure to formaldehyde (years of exposure) and micronucleus frequency in peripheral blood lymphocytes (r = 0.401; p < 0.001) and in epithelial cells (r = 0.209; p < 0.01). Conclusions - The population studied is exposed to high peak concentrations of formaldehyde with a long-term exposure. These two aspects, cumulatively, can be the cause of the observed genotoxic endpoint effects. The association of these cytogenetic effects with formaldehyde exposure gives important information to risk assessment process and may also be used to assess health risks for exposed workers.por
dc.identifier.citationViegas S, Ladeira C, Nunes C, Malta-Vacas J, Gomes M, Brito M, et al. Genotoxic effects in occupational exposure to formaldehyde: a study in anatomy and pathology laboratories and formaldehyde-resins production. J Occup Med Toxicol. 2010;5(1):25.por
dc.identifier.issn1745-6673
dc.identifier.urihttp://hdl.handle.net/10400.21/3068
dc.language.isoengpor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.occup-med.com/content/5/1/25por
dc.subjectOccupational healthpor
dc.subjectFormaldehydepor
dc.subjectGenotoxic effectspor
dc.subjectResinspor
dc.titleGenotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins productionpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage25por
oaire.citation.titleJournal of Occupational Medicine and Toxicologypor
oaire.citation.volume5por
person.familyNameViegas
person.familyNameLadeira
person.familyNameBrito
person.givenNameSusana
person.givenNameCarina
person.givenNameMiguel
person.identifier248817
person.identifier144237
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridI-4053-2012
person.identifier.ridJ-2572-2012
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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