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Alternative sérum biomarkers of bacteraemia for intensive care unit patients

2023-06Conference object Restricted access
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dc.contributor.authorAraújo, Rúben
dc.contributor.authorVon Rekowski, Cristiana
dc.contributor.authorBento, Luís
dc.contributor.authorFonseca, Tiago AH
dc.contributor.authorCalado, Cecília
dc.date.accessioned2024-03-25T16:05:15Z
dc.date.available2024-03-25T16:05:15Z
dc.date.issued2023-06
dc.description.abstractThe diagnosis of infections in hospital or clinical settings usually involves a series of time-consuming steps, including biological sample collection, culture growth of the organism isolation and subsequent characterization. For this, there are diverse infection biomarkers based on blood analysis, however, these are of limited use in patients presenting confound processes as inflammatory process as occurring at intensive care units. In this preliminary study, the application of serum analysis by FTIR spectroscopy, to predict bacteraemia in 102 critically ill patients in an ICU was evaluated. It was analysed the effect of spectra pre-processing methods and spectral sub-regions on t-distributed stochastic neighbour embedding. By optimizing Support Vector Machine (SVM) models, based on normalised second derivative spectra of a smaller subregion, it was possible to achieve a good bacteraemia predictive model with a sensitivity and specificity of 76%. Since FTIR spectra of serum is acquired in a simple, economic and rapid mode, the technique presents the potential to be a cost-effective methodology of bacteraemia identification, with special relevance in critically ill patients, where a rapid infection diagnostic will allow to avoid the unnecessary use of antibiotics, which ultimately will ease the load on already fragile patients' metabolism.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationR. Araújo, L. Ramalhete, T. Fonseca, C. Von Rekowski, L. Bento and C. R. C. Calado, "Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients," 2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG), Porto, Portugal, 2023, pp. 21-24, doi: 10.1109/ENBENG58165.2023.10175340.pt_PT
dc.identifier.doi10.1109/enbeng58165.2023.10175340pt_PT
dc.identifier.issn979-8-3503-2257-6
dc.identifier.urihttp://hdl.handle.net/10400.21/17217
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)pt_PT
dc.relationNeproMD/ISEL/2020pt_PT
dc.relation.publisherversionhttps://ieeexplore.ieee.org/document/10175340pt_PT
dc.subjectFTIR spectroscopypt_PT
dc.subjectIntensive Care Unitpt_PT
dc.subjectInfectionpt_PT
dc.subjectBiomarkerspt_PT
dc.titleAlternative sérum biomarkers of bacteraemia for intensive care unit patientspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/DSAIPA%2FDS%2F0117%2F2020/PT
oaire.citation.conferencePlacePortugalpt_PT
oaire.citation.endPage24pt_PT
oaire.citation.startPage21pt_PT
oaire.citation.titleIEEE 7th Portuguese Meeting on Bioengineering, ENBENG 2023pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameAraújo
person.familyNameVon Rekowski
person.familyNameBento
person.familyNameHenrique Fonseca
person.familyNameCalado
person.givenNameRúben Alexandre Dinis
person.givenNameCristiana
person.givenNameLuís
person.givenNameTiago Alexandre
person.givenNameCecília
person.identifier1960990
person.identifier130332
person.identifier.ciencia-id9A18-BFDC-ED95
person.identifier.ciencia-idE711-FA12-4784
person.identifier.ciencia-id8F1D-1D48-8551
person.identifier.ciencia-id9418-E320-3177
person.identifier.orcid0000-0002-9369-6486
person.identifier.orcid0009-0009-6843-1935
person.identifier.orcid0000-0002-0260-003X
person.identifier.orcid0000-0003-0741-2211
person.identifier.orcid0000-0002-5264-9755
person.identifier.ridL-6623-2018
person.identifier.ridE-2102-2014
person.identifier.scopus-author-id6603163260
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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