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Application of alkaline comet assay in human biomonitoring for genotoxicity: a study on occupational exposure to cytostatics

2014-09Conference object Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGomes, M. C.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2014-10-14T12:52:47Z
dc.date.available2014-10-14T12:52:47Z
dc.date.issued2014-09
dc.description.abstractThe use of cytostatics drugs in anticancer therapy is increasing. Health care workers can be occupationally exposed to these drugs classified as carcinogenic, mutagenic or teratogenic. Cytostatics drugs are a heterogeneous group of chemicals widely used in the treatment of cancer, nevertheless have been proved to be also mutagens, carcinogens and teratogens. Workers may be exposed to this drug, being in the hospital settings the main focus dwelled upon the pharmacy, and nursing personnel. Alkaline comet assay is one of the most promising short-term genotoxicity assays for human risk assessment, being recommended to monitor populations chronically exposed to genotoxic agents. DNA glycosylase (OGG1) represents the main mechanism of protecting the integrity of the human DNA with respect to 8-OHdG, the most well studied biomarker of oxidative damage.por
dc.description.sponsorshipAutoridade para as Condições de Trabalho. AP Tox for AP Tox grant.por
dc.identifier.citationLadeira C, Viegas S, Carolino E, Gomes MC, Brito M. Application of alkaline comet assay in human biomonitoring for genotoxicity: a study on occupational exposure to cytostatics. In EUROTOX 2014 – 50th Congress of the European Societies of Toxicology, Edimburg (UK), September 7-10, 2014.por
dc.identifier.urihttp://hdl.handle.net/10400.21/3868
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationProjecto 036APJ/09por
dc.subjectCytostatic drugspor
dc.subjectBiomonitoringpor
dc.subjectOccupational exposurepor
dc.subjectGenotoxicitypor
dc.subjectComet assaypor
dc.subjectHospitalpor
dc.titleApplication of alkaline comet assay in human biomonitoring for genotoxicity: a study on occupational exposure to cytostaticspor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceEdimburgopor
person.familyNameLadeira
person.familyNameViegas
person.familyNameCarolino
person.familyNameBrito
person.givenNameCarina
person.givenNameSusana
person.givenNameElisabete
person.givenNameMiguel
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
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person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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