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Overdiagnosis of COPD in subjects with unobstructed spirometry

2019-08Journal article Open access
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dc.contributor.authorSator, Lea
dc.contributor.authorHorner, Andreas
dc.contributor.authorStudnicka, Michael
dc.contributor.authorLamprecht, Bernd
dc.contributor.authorKaiser, Bernhard
dc.contributor.authorMcBurnie, Mary Ann
dc.contributor.authorBuist, A. Sonia
dc.contributor.authorGnatiuc, Luisa
dc.contributor.authorMannino, David M.
dc.contributor.authorJanson, Christer
dc.contributor.authorBateman, Eric D.
dc.contributor.authorBurney, Peter
dc.contributor.authorZhong, NanShan
dc.contributor.authorLiu, Shengming
dc.contributor.authorLu, Jiachun
dc.contributor.authorRan, Pixin
dc.contributor.authorWang, Dali
dc.contributor.authorZheng, Jingping
dc.contributor.authorZhou, Yumin
dc.contributor.authorKocabaş, Ali
dc.contributor.authorHancioglu, Attila
dc.contributor.authorHanta, Ismail
dc.contributor.authorKuleci, Sedat
dc.contributor.authorTurkyilmaz, Ahmet Sinan
dc.contributor.authorUmut, Sema
dc.contributor.authorUnalan, Turgay
dc.contributor.authorStudnicka, Michael
dc.contributor.authorDawes, Torkil
dc.contributor.authorLamprecht, Bernd
dc.contributor.authorSator, Lea
dc.contributor.authorBateman, Eric
dc.contributor.authorJithoo, Anamika
dc.contributor.authorAdams, Desiree
dc.contributor.authorBarnes, Edward
dc.contributor.authorFreeman, Jasper
dc.contributor.authorHayes, Anton
dc.contributor.authorHlengwa, Sipho
dc.contributor.authorJohannisen, Christine
dc.contributor.authorKoopman, Mariana
dc.contributor.authorLouw, Innocentia
dc.contributor.authorLudick, Ina
dc.contributor.authorOlckers, Alta
dc.contributor.authorRyck, Johanna
dc.contributor.authorStorbeck, Janita
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorBenedikdtsdottir, Bryndis
dc.contributor.authorJörundsdottir, Kristin
dc.contributor.authorGudmundsdottir, Lovisa
dc.contributor.authorGudmundsdottir, Sigrun
dc.contributor.authorGundmundsson, Gunnar
dc.contributor.authorNizankowska-Mogilnicka, Ewa
dc.contributor.authorFrey, Jakub
dc.contributor.authorHarat, Rafal
dc.contributor.authorMejza, Filip
dc.contributor.authorNastalek, Pawel
dc.contributor.authorPajak, Andrzej
dc.contributor.authorSkucha, Wojciech
dc.contributor.authorSzczeklik, Andrzej
dc.contributor.authorTwardowska, Magda
dc.contributor.authorWelte, Tobias
dc.contributor.authorBodemann, Isabelle
dc.contributor.authorGeldmacher, Henning
dc.contributor.authorSchweda-Linow, Alexandra
dc.contributor.authorGulsvik, Amund
dc.contributor.authorEndresen, Tina
dc.contributor.authorSvendsen, Lene
dc.contributor.authorTan, Wan C.
dc.contributor.authorWang, Wen
dc.contributor.authorMannino, David M.
dc.contributor.authorCain, John
dc.contributor.authorCopeland, Rebecca
dc.contributor.authorHazen, Dana
dc.contributor.authorMethvin, Jennifer
dc.contributor.authorDantes, Renato B.
dc.contributor.authorAmarillo, Lourdes
dc.contributor.authorBerratio, Lakan U.
dc.contributor.authorFernandez, Lenora C.
dc.contributor.authorFrancisco, Norberto A.
dc.contributor.authorGarcia, Gerard S.
dc.contributor.authorde Guia, Teresita S.
dc.contributor.authorIdolor, Luisito F.
dc.contributor.authorNaval, Sullian S.
dc.contributor.authorReyes, Thessa
dc.contributor.authorRoa, Camilo C.
dc.contributor.authorSanchez, Ma. Flordeliza
dc.contributor.authorSimpao, Leander P.
dc.contributor.authorJenkins, Christine
dc.contributor.authorMarks, Guy
dc.contributor.authorBird, Tessa
dc.contributor.authorEspinel, Paola
dc.contributor.authorHardaker, Kate
dc.contributor.authorToelle, Brett
dc.contributor.authorBurney, Peter G.J.
dc.contributor.authorAmor, Caron
dc.contributor.authorPotts, James
dc.contributor.authorTumilty, Michael
dc.contributor.authorMcLean, Fiona
dc.contributor.authorWouters, E.F.M.
dc.contributor.authorWesseling, G.J.
dc.contributor.authorBárbara, Cristina
dc.contributor.authorRodrigues, Fátima
dc.contributor.authorDias, Hermínia Brites
dc.contributor.authorCardoso, João
dc.contributor.authorAlmeida, João
dc.contributor.authorMatos, Maria João
dc.contributor.authorSimão, Paula
dc.contributor.authorSantos, Moutinho
dc.contributor.authorFerreira, Reis
dc.contributor.authorJanson, Christer
dc.contributor.authorOlafsdottir, Inga Sif
dc.contributor.authorNisser, Katarina
dc.contributor.authorSpetz-Nyström, Ulrike
dc.contributor.authorHägg, Gunilla
dc.contributor.authorLund, Gun-Marie
dc.contributor.authorJõgi, Rain
dc.contributor.authorLaja, Hendrik
dc.contributor.authorUlst, Katrin
dc.contributor.authorZobel, Vappu
dc.contributor.authorLill, Toomas-Julius
dc.contributor.authorKoul, Parvaiz A.
dc.contributor.authorMalik, Sajjad
dc.contributor.authorHakim, Nissar A.
dc.contributor.authorKhan, Umar Hafiz
dc.contributor.authorChowgule, Rohini
dc.contributor.authorShetye, Vasant
dc.contributor.authorRaphael, Jonelle
dc.contributor.authorAlmeda, Rosel
dc.contributor.authorTawde, Mahesh
dc.contributor.authorTadvi, Rafiq
dc.contributor.authorKatkar, Sunil
dc.contributor.authorKadam, Milind
dc.contributor.authorDhanawade, Rupesh
dc.contributor.authorGhurup, Umesh
dc.contributor.authorHarrabi, Imed
dc.contributor.authorDenguezli, Myriam
dc.contributor.authorTabka, Zouhair
dc.contributor.authorDaldoul, Hager
dc.contributor.authorBoukheroufa, Zaki
dc.contributor.authorChouikha, Firas
dc.contributor.authorKhalifa, Wahbi Belhaj
dc.contributor.authorIdolor, Luisito F.
dc.contributor.authorde Guia, Teresita S.
dc.contributor.authorFrancisco, Norberto A.
dc.contributor.authorRoa, Camilo C.
dc.contributor.authorAyuyao, Fernando G.
dc.contributor.authorTady, Cecil Z.
dc.contributor.authorTan, Daniel T.
dc.contributor.authorBanal-Yang, Sylvia
dc.contributor.authorBalanag, Vincent M.
dc.contributor.authorReyes, Maria Teresita N.
dc.contributor.authorDantes, Renato B.
dc.contributor.authorJuvekar, Sanjay
dc.contributor.authorHirve, Siddhi
dc.contributor.authorSambhudas, Somnath
dc.contributor.authorChaidhary, Bharat
dc.contributor.authorTambe, Meera
dc.contributor.authorPingale, Savita
dc.contributor.authorUmap, Arati
dc.contributor.authorUmap, Archana
dc.contributor.authorShelar, Nitin
dc.contributor.authorDevchakke, Sampada
dc.contributor.authorChaudhary, Sharda
dc.contributor.authorBondre, Suvarna
dc.contributor.authorWalke, Savita
dc.contributor.authorGawhane, Ashleshsa
dc.contributor.authorSapkal, Anil
dc.contributor.authorArgade, Rupali
dc.contributor.authorGaikwad, Vijay
dc.contributor.authorSalvi, Sundeep
dc.contributor.authorBrashier, Bill
dc.contributor.authorLondhe, Jyoti
dc.contributor.authorMadas, Sapna
dc.contributor.authorObaseki, Daniel
dc.contributor.authorErhabor, Gregory
dc.contributor.authorAwopeju, Olayemi
dc.contributor.authorAdewole, Olufemi
dc.date.accessioned2022-05-09T17:20:04Z
dc.date.available2022-08-01T00:30:20Z
dc.date.issued2019-08
dc.description.abstractBackground: There are several reports on the underdiagnosis of COPD, while little is known about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the prevalence of spirometrically defined false-positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries participating in the BOLD Study between 2003 and 2012. Methods: A false-positive diagnosis of COPD was considered when participants reported a doctor's diagnosis of COPD, but postbronchodilator spirometry was unobstructed (FEV1/FVC > LLN). Additional analyses were performed using the fixed ratio criterion (FEV1/FVC < 0.7). Results: Among 16,177 participants, 919 (5.7%) reported a previous medical diagnosis of COPD. Postbronchodilator spirometry was unobstructed in 569 subjects (61.9%): false-positive COPD. A similar rate of overdiagnosis was seen when using the fixed ratio criterion (55.3%). In a subgroup analysis excluding participants who reported a diagnosis of "chronic bronchitis" or "emphysema" (n = 220), 37.7% had no airflow limitation. The site-specific prevalence of false-positive COPD varied greatly, from 1.9% in low- to middle-income countries to 4.9% in high-income countries. In multivariate analysis, overdiagnosis was more common among women, and was associated with higher education; former and current smoking; the presence of wheeze, cough, and phlegm; and concomitant medical diagnosis of asthma or heart disease. Among the subjects with false-positive COPD, 45.7% reported current use of respiratory medication. Excluding patients with reported asthma, 34.4% of those with normal spirometry still used a respiratory medication. Conclusions: False-positive COPD is frequent. This might expose nonobstructed subjects to possible adverse effects of respiratory medication.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSator L, Horner A, Studnicka M, Lamprecht B, Kaiser B, BOLD Collaborative Research Group [Dias HB]. Overdiagnosis of COPD in subjects with unobstructed spirometry. Chest. 2019;156(2):277-88.pt_PT
dc.identifier.doi10.1016/j.chest.2019.01.015pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14633
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0012369219300662pt_PT
dc.subjectChronic obstructive pulmonary diseasept_PT
dc.subjectCOPDpt_PT
dc.subjectFalse positive diagnosispt_PT
dc.subjectMisdiagnosispt_PT
dc.subjectOverdiagnosispt_PT
dc.subjectOvertreatmentpt_PT
dc.titleOverdiagnosis of COPD in subjects with unobstructed spirometrypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage288pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage277pt_PT
oaire.citation.titleChestpt_PT
oaire.citation.volume156pt_PT
person.familyNameDias
person.givenNameMaria Hermínia Monteiro Brites
person.identifier.ciencia-idE211-FB1B-04E3
person.identifier.orcid0000-0003-1257-8734
person.identifier.ridAFL-8310-2022
person.identifier.scopus-author-id55671930200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb7b7e7d9-83b2-4d63-9176-4ed73cf6b939
relation.isAuthorOfPublication.latestForDiscoveryb7b7e7d9-83b2-4d63-9176-4ed73cf6b939

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