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Advisor(s)
Abstract(s)
Aspergillus section Fumigati is one of the most common sections, in the environment. It has been found in different occupational environments, such as sawmills and waste sorting. Its cryptic species show intrinsic resistance to several antifungals. Resistance in A. fumigatus is emerging due to selective pressure caused by the prolonged use of azoles. It is often associated with mutations in the Cyp51A gene. The fungal priority pathogens list (WHO), includes A. fumigatus with critical priority. Further analysis to identify potential resistance mechanisms and mutations is needed. Objective: This evaluation aims to offer a protocol for mutation detection in Aspergillus section Fumigati isolates. It will contribute to the development of guidance that can support future occupational exposure assessments.
Description
This project was supported by FCT/MCTES UIDP/05608/2020, and UIDB/05608/2020. This work is also supported by national funds through FCT/MCTES/FSE/UE, 2023.01366.BD; UI/BD/153746/2022 and CE3C unit UIDB/00329/2020; UI/BD/151431/2021; and Instituto Politécnico de Lisboa, national support through IPL/2022/InChildhealth/BI/12M; IPL/IDI&CA2023/FoodAIIEU_ESTeSL; IPL/IDI&CA2023/ASPRisk_ESTeSL; IPL/IDI&CA2023/ARAFSawmills_ESTeSL.
Keywords
Occupational health Occupational exposure Aspergillus fumigatus Mutation detection Protocol FCT/MCTES/FSE/UE, 2023.01366.BD UI/BD/153746/2022 CE3C unit UIDB/00329/2020 UI/BD/151431/2021 IPL/2022/InChildhealth/BI/12M IPL/IDI&CA2023/FoodAIIEU_ESTeSL IPL/IDI&CA2023/ASPRisk_ESTeSL IPL/IDI&CA2023/ARAFSawmills_ESTeSL FCT_UIDP/05608/2020 FCT_UIDB/05608/2020
Citation
Dias M, Rodriguez M, Vasques C, Riesenberger B, Marques L, Gomes B, Pena P, Cervantes R, Viegas S, Viegas C. Budget-friendly protocol for TR34/L98H and TR46/Y121F/T289A mutation detection in Aspergillus section Fumigati isolates. In: SHO 2024 [hybrid], Porto (Portugal), 4-5 de julho de 2024.