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Authors
Advisor(s)
Abstract(s)
A Osteopatia é uma ciência holística baseada no diagnóstico diferencial, tratamento e promoção da saúde, sem recurso a fármacos ou a cirurgia. A utilização de citocinas como marcadores biológicos com uma importante função na comunicação entre os sistemas imunológico e nervoso tem permitido confirmar a eficácia clínica da osteopatia, de um ponto de vista laboratorial e analítico. Os objetivos desta revisão sistemática são investigar qual a relação entre os vários tipos de citocinas e os sinais, sintomas ou queixas apresentadas em consulta de osteopatia, e determinar que citocinas possuem evidência científica para ser utilizadas no apoio ao diagnóstico/monitorização das condições alvo ao tratamento osteopático. Foram seguidas as diretrizes PRISMA, tendo sido incluídos 5 artigos com recurso às bases de dados eletrónicas Pubmed, Web of Science, Scopus e iJom, durante o processo de pesquisa realizado entre fevereiro e abril de 2022. Apenas foram incluídos estudos experimentais publicados após 2000 em português e inglês, com o foco em pacientes adultos que apresentassem queixas músculo-esqueléticas sujeitos a uma análise dos níveis de citocinas e a uma intervenção osteopática. Com base nos resultados obtidos, verificou-se que as citocinas como IL-8, TNF-α, MCP-1, MIP-1α e G-CSF podem ser utilizadas como marcadores biológicos na investigação em Osteopatia, porém com algumas limitações descritas pelos próprios autores como a dificuldade do processo de medição das mesmas. É necessário realizar mais investigação dentro desta área a fim de ultrapassar algumas destas limitações.
ABSTRACT - Osteopathy is a holistic science based on differential diagnosis, treatment, and health promotion, without the use of drugs or surgery. The use of cytokines as biological markers with an important role in immunological and nervous communication has allowed for confirming the clinical efficacy of osteopathy, from a laboratory and analytical point of view. The objectives of this systematic review are to investigate the relationship between the various types of cytokines and the signs, symptoms, or complaints presented in an osteopathy consultation, and to determine which cytokines have scientific evidence to be used to support the diagnosis/monitoring of the target conditions for osteopathic treatment. The PRISMA guidelines were followed, and 5 articles were included using the electronic databases Pubmed, Web of Science, Scopus, and iJom, during the research process carried out between February and April 2022. Only experimental studies published after 2000 in Portuguese and English were accepted, focusing on adult patients with musculoskeletal complaints subjected to an analysis of cytokine levels and an osteopathic intervention. Based on the results obtained, we found that cytokines such as IL-8, TNF-α, MCP-1, MIP-1α, and G-CSF can be used as biological markers in Osteopathy research, however, with some limitations described by the authors themselves, such as the difficulty in the measurement process. More research is needed within this area in order to overcome some of these limitations.
ABSTRACT - Osteopathy is a holistic science based on differential diagnosis, treatment, and health promotion, without the use of drugs or surgery. The use of cytokines as biological markers with an important role in immunological and nervous communication has allowed for confirming the clinical efficacy of osteopathy, from a laboratory and analytical point of view. The objectives of this systematic review are to investigate the relationship between the various types of cytokines and the signs, symptoms, or complaints presented in an osteopathy consultation, and to determine which cytokines have scientific evidence to be used to support the diagnosis/monitoring of the target conditions for osteopathic treatment. The PRISMA guidelines were followed, and 5 articles were included using the electronic databases Pubmed, Web of Science, Scopus, and iJom, during the research process carried out between February and April 2022. Only experimental studies published after 2000 in Portuguese and English were accepted, focusing on adult patients with musculoskeletal complaints subjected to an analysis of cytokine levels and an osteopathic intervention. Based on the results obtained, we found that cytokines such as IL-8, TNF-α, MCP-1, MIP-1α, and G-CSF can be used as biological markers in Osteopathy research, however, with some limitations described by the authors themselves, such as the difficulty in the measurement process. More research is needed within this area in order to overcome some of these limitations.
Description
Mestrado em Tecnologias Clínico-Laboratoriais
Keywords
Osteopatia Tratamento osteopático Medicina osteopática Citocinas Osteopathy Osteopathic treatment Osteopathic medicine Cytokines
Citation
Coelho DE. O papel das citocinas no apoio à monitorização e diagnóstico das condições alvo ao tratamento osteopático: revisão sistemática da literatura [dissertation]. Lisboa: Escola Superior de Tecnologia da Saúde de Lisboa/Instituto Politécnico de Lisboa; 2022.
Publisher
Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa