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Effects of apigenin on gastric cancer cells

2024-02Journal article Open access
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dc.contributor.authorPratas, Ana
dc.contributor.authorMalhão, Beatriz
dc.contributor.authorPalma, Raquel
dc.contributor.authorMendonça, Paula
dc.contributor.authorCervantes, Renata
dc.contributor.authorMarques-Ramos, Ana
dc.date.accessioned2024-02-12T12:26:27Z
dc.date.available2024-02-12T12:26:27Z
dc.date.issued2024-02
dc.descriptionThe H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020. This work was part of the IPL/2021/GATumor_ESTeSL project.pt_PT
dc.description.abstractGastric Cancer (GC) is one of the most prevalent cancers worldwide. As the currently available therapeutic options are invasive, new and more benign options are being explored. One of which is Apigenin (Api), a natural flavonoid found in fruits and vegetables, such as celery, parsley, garlic, bell pepper, and chamomile tea. Api has known anti-inflammatory, -oxidant, and -proliferative properties in several diseases, and its potential as an anticancer compound has been explored. Here we systematize the available data regarding the effects of Api on GC cells, in terms of cell proliferation, apoptosis, Helicobacter pylori (H. pylori) infection, and molecular targets. From the literature, it is possible to conclude that Api inhibits cell growth in a dose- and time-dependent manner, which is accompanied by the reduction of clone formation and induction of apoptosis. This occurs through the Akt/Bad/Bcl2/Bax axis that activates the mitochondrial pathway of apoptosis, resulting in the restriction of cell proliferation. Additionally, it seems that the anti-proliferative potential of Api on GC cells is particularly relevant in a more aggressive GC phenotype but can also affect normal gastric cells. This indicates that this flavonoid must be used in low-to-moderate doses to avoid side effects induced by disturbance of the normal epithelium. In H. Pylori-infected cells, the literature demonstrates that Api reduces inflammation by diminishing the levels of H. pylori colonization, preventing NF-kB activation, and diminishing the production of reactive oxygen specimens (ROS). Accordingly, GC Api seems to regulate different hallmarks of cancer, such as cell proliferation, apoptosis, cell migration, inflammation, and oxidative stress, demonstrating its potential as an anti-GC compound.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPratas A, Malhão B, Palma R, Mendonça P, Cervantes R, Marques-Ramos A. Effects of apigenin on gastric cancer cells. Biomed Pharmacother. 2024;172:116251.pt_PT
dc.identifier.doi10.1016/j.biopha.2024.116251pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17102
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIPL/2021/GATumor_ESTeSLpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S075333222400132Xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectApigeninpt_PT
dc.subjectApoptosispt_PT
dc.subjectCell proliferationpt_PT
dc.subjectGastric cancerpt_PT
dc.subjectMolecular targetspt_PT
dc.subjectIPL/2021/GATumor_ESTeSLpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleEffects of apigenin on gastric cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage116251pt_PT
oaire.citation.titleBiomedicine & Pharmacotherapypt_PT
oaire.citation.volume172pt_PT
person.familyNameWellenkamp de Carvalho Freire de Cervantes
person.givenNameRenata
person.identifier.ciencia-id6018-3CC9-B640
person.identifier.orcid0000-0001-5990-4168
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication28678633-1f6a-4b79-8150-12a857f4a531
relation.isAuthorOfPublication.latestForDiscovery28678633-1f6a-4b79-8150-12a857f4a531

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