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Comparison of different breast planning techniques and algorithms for radiation therapy treatment

2013-06Journal article Open access
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dc.contributor.authorBorges, C.
dc.contributor.authorCunha, Gilda
dc.contributor.authorMonteiro-Grillo, I.
dc.contributor.authorVaz, P.
dc.contributor.authorTeixeira, Nuno
dc.date.accessioned2013-12-31T18:08:01Z
dc.date.available2013-12-31T18:08:01Z
dc.date.issued2013-06
dc.description.abstractThis work aims at investigating the impact of treating breast cancer using different radiation therapy (RT) techniques – forwardly-planned intensity-modulated, f-IMRT, inversely-planned IMRT and dynamic conformal arc (DCART) RT – and their effects on the whole-breast irradiation and in the undesirable irradiation of the surrounding healthy tissues. Two algorithms of iPlan BrainLAB treatment planning system were compared: Pencil Beam Convolution (PBC) and commercial Monte Carlo (iMC). Seven left-sided breast patients submitted to breast-conserving surgery were enrolled in the study. For each patient, four RT techniques – f-IMRT, IMRT using 2-fields and 5-fields (IMRT2 and IMRT5, respectively) and DCART – were applied. The dose distributions in the planned target volume (PTV) and the dose to the organs at risk (OAR) were compared analyzing dose–volume histograms; further statistical analysis was performed using IBM SPSS v20 software. For PBC, all techniques provided adequate coverage of the PTV. However, statistically significant dose differences were observed between the techniques, in the PTV, OAR and also in the pattern of dose distribution spreading into normal tissues. IMRT5 and DCART spread low doses into greater volumes of normal tissue, right breast, right lung and heart than tangential techniques. However, IMRT5 plans improved distributions for the PTV, exhibiting better conformity and homogeneity in target and reduced high dose percentages in ipsilateral OAR. DCART did not present advantages over any of the techniques investigated. Differences were also found comparing the calculation algorithms: PBC estimated higher doses for the PTV, ipsilateral lung and heart than the iMC algorithm predicted.por
dc.identifier.citationBorges C, Cunha G, Monteiro-Grillo I, Vaz P, Teixeira N. Comparison of different breast planning techniques and algorithms for radiation therapy treatment. Phys Med. 2013 Jun 1. [Epub ahead of print]por
dc.identifier.issn1724-191X
dc.identifier.urihttp://hdl.handle.net/10400.21/3035
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAssociazione Italiana di Fisica Medicapor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1120179713000562por
dc.subjectRadiotherapypor
dc.subjectBreast cancerpor
dc.subjectIrradiation techniquespor
dc.subjectCalculationpor
dc.subjectAlgorithmspor
dc.titleComparison of different breast planning techniques and algorithms for radiation therapy treatmentpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titlePhysica Medicapor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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