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Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells

2018-01-01Journal article Restricted access
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dc.contributor.authorTeixeira, Ricardo G.
dc.contributor.authorBrás, Ana Rita
dc.contributor.authorCôrte-Real, Leonor
dc.contributor.authorTatikonda, Rajendhraprasad
dc.contributor.authorSanches, Anabela
dc.contributor.authorRobalo, Maria Paula
dc.contributor.authorAvecilla, Fernando
dc.contributor.authorMoreira, Tiago
dc.contributor.authorGarcia, M. Helena
dc.contributor.authorHaukka, Matti
dc.contributor.authorPreto, Ana
dc.contributor.authorValente, Andreia
dc.date.accessioned2018-12-11T10:47:15Z
dc.date.available2018-12-11T10:47:15Z
dc.date.issued2018-01-01
dc.description.abstractThree new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(eta(5)-MeCp)(PPh3)(2)Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P (1) over bar. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(eta(5)-MeCp)(PPh3)(L1)] [CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4-6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent. (C) 2017 Elsevier Masson SAS. All rights reserved.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTEIXEIRA, Ricardo G.; [et al] – Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells. European Journal of Medicinal Chemistry. ISSN 0223-5234. Vol. 143, (2018), pp. 503-514pt_PT
dc.identifier.doi10.1016/j.ejmech.2017.11.059pt_PT
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.urihttp://hdl.handle.net/10400.21/9156
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIF/01302/2013 - Investigator FCT Initiativept_PT
dc.relationSFRH/BD/100515/2014 - FCTpt_PT
dc.relationCM1302 - COST actionpt_PT
dc.relation.publisherversionhttps://reader.elsevier.com/reader/sd/pii/S0223523417309625?token=3DDD0711C2C2751589EADC9C8D1B5104FEFE4E8680F9BC52E3D1AC2E91D9B20D681D19B6D6374942BC91D2DF5A51C8E2pt_PT
dc.subjectRuthenium methylcyclopentadienylpt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectApoptosispt_PT
dc.subjectCompostos organometálicospt_PT
dc.subjectApoptosept_PT
dc.subjectCancro colo-retalpt_PT
dc.titleNovel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIA%2F04050%2F2013/PT
oaire.citation.endPage514pt_PT
oaire.citation.startPage503pt_PT
oaire.citation.titleEuropean Journal of Medicinal Chemistrypt_PT
oaire.citation.volume143pt_PT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameCôrte-Real
person.familyNameTatikonda
person.familyNameRobalo
person.familyNameAnselmo Viegas Garcia
person.familyNameHaukka
person.givenNameLeonor
person.givenNameRajendhraprasad
person.givenNameMaria Paula
person.givenNameMaria Helena
person.givenNameMatti
person.identifierH-2175-­2013
person.identifier.ciencia-idF112-59D7-0984
person.identifier.ciencia-idE11C-A704-9C18
person.identifier.ciencia-id5414-9AEF-4194
person.identifier.orcid0000-0002-4974-1075
person.identifier.orcid0000-0003-1277-3492
person.identifier.orcid0000-0002-8200-6910
person.identifier.orcid0000-0002-4344-2218
person.identifier.orcid0000-0002-6744-7208
person.identifier.ridH-5636-2013
person.identifier.ridB-2002-2012
person.identifier.scopus-author-id55627880500
person.identifier.scopus-author-id9269662100
person.identifier.scopus-author-id6507884466
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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