Repository logo

Browsing by Issue Date, starting with "2018-01-01"

Filter results by year or month
Now showing 1 - 2 of 2
  • Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
    Publication . Teixeira, Ricardo G.; Brás, Ana Rita; Côrte-Real, Leonor; Tatikonda, Rajendhraprasad; Sanches, Anabela; Robalo, Maria Paula; Avecilla, Fernando; Moreira, Tiago; Garcia, M. Helena; Haukka, Matti; Preto, Ana; Valente, Andreia
    Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(eta(5)-MeCp)(PPh3)(2)Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P (1) over bar. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(eta(5)-MeCp)(PPh3)(L1)] [CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4-6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent. (C) 2017 Elsevier Masson SAS. All rights reserved.
    2018-01-01Journal article Restricted access Show more
  • Multiobjective optimization of ceramic-metal functionally graded plates using a higher order model
    Publication . Franco Correia, Victor; Madeira, JFA; Araújo, Aurélio L.; Mota Soares, Cristóvão Manuel
    A methodology of multiobjective design optimization of ceramic–metal composite plates with functionally graded materials, with properties varying through the thickness direction, obtained by an adequate variation of volume fractions of the constituent materials, is presented in this paper. Constrained optimization is conducted for different behavior objectives like the maximization of buckling load or fundamental natural frequency. Mass minimization and material cost minimization are also considered. The optimization problems are constrained by stress based failure criteria and other structural response constraints or manufacturing limitations. The design variables are the index of the power-law distribution in the metal-ceramic graded material and the thicknesses of the graded material and/or the metal and ceramic faces. An equivalent single layer finite element plate model having a displacement field based on a higher order shear deformation theory, accounting for the temperature dependency of the material properties, was developed and validated for the analysis of through-the-thickness ceramic-metal functionally graded plates. The optimization problems are solved with two direct search derivative-free algorithms: GLODS (Global and Local Optimization using Direct Search) and DMS (Direct MultiSearch). DMS, the multiobjective optimization solver, is started from a set of local minimizers which are initially determined by the global optimizer algorithm GLODS for each one of the objective functions.
    2018-01-01Journal article Restricted access Show more