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Improvement of glycaemia and endothelial function by a new low-dose curcuminoid in an animal model of type 2 diabetes

2022-05-18Journal article Open access
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dc.contributor.authorOliveira, Sara
dc.contributor.authorAlfredo, Tamaeh Monteiro-Alfredo; Tamaeh Monteiro
dc.contributor.authorHenriques, Rita
dc.contributor.authorRibeiro
dc.contributor.authorSeica, Raquel
dc.contributor.authorCruz, Maria Teresa
dc.contributor.authorCabral, C
dc.contributor.authorFernandes, Rosa
dc.contributor.authorPiedade, Maria
dc.contributor.authorRobalo, Maria Paula
dc.contributor.authorMatafome, Paulo
dc.contributor.authorSilva, Sónia
dc.date.accessioned2022-06-23T07:14:48Z
dc.date.available2022-06-23T07:14:48Z
dc.date.issued2022-05-18
dc.description.abstractCurcumin has been suggested as a promising treatment for metabolic diseases, but the high doses required limit its therapeutic use. In this study, a new curcuminoid is synthesised to increase curcumin anti-inflammatory and antioxidant potential and to achieve hypoglycaemic and protective vascular effects in type 2 diabetic rats in a lower dose. In vitro, the anti-inflammatory effect was determined through the Griess reaction, and the antioxidant activity through ABTS and TBARS assays. In vivo, Goto-Kakizaki rats were treated for 2 weeks with the equimolar dose of curcumin (40 mg/kg/day) or curcuminoid (52.4 mg/kg/day). Fasting glycaemia, insulin tolerance, plasma insulin, insulin signalling, serum FFA, endothelial function and several markers of oxidative stress were evaluated. Both compounds presented a significant anti-inflammatory effect. Moreover, the curcuminoid had a marked hypoglycaemic effect, accompanied by higher GLUT4 levels in adipose tissue. Both compounds increased NO-dependent vasorelaxation, but only the curcuminoid exacerbated the response to ascorbic acid, consistent with a higher decrease in vascular oxidative and nitrosative stress. SOD1 and GLO1 levels were increased in EAT and heart, respectively. Altogether, these data suggest that the curcuminoid developed here has more pronounced effects than curcumin in low doses, improving the oxidative stress, endothelial function and glycaemic profile in type 2 diabetes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOLIVEIRA, Sara; [et al] – Improvement of glycaemia and endothelial function by a new low-dose curcuminoid in an animal model of type 2 diabetes. International Journal of Molecular Sciences. eISSN 1422-0067. Vol. 23, N.º 10 (2022), pp. 1-18.pt_PT
dc.identifier.doi10.3390/ijms23105652pt_PT
dc.identifier.eissn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.21/14719
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPOCI-01-0145-FEDER-029369 - COMPETE 2020pt_PT
dc.relationCNC. IBILI
dc.relationCentro de Química Estrutural
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/10/5652pt_PT
dc.subjectCurcuminoidpt_PT
dc.subjectEndothelial dysfunctionpt_PT
dc.subjectGlycaemiapt_PT
dc.subjectOxidative stresspt_PT
dc.subjectType 2 diabetes mellituspt_PT
dc.titleImprovement of glycaemia and endothelial function by a new low-dose curcuminoid in an animal model of type 2 diabetespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCNC. IBILI
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FNEU%2F04539%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT
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oaire.citation.endPage18pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume23pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
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person.familyNameFerreira Oliveira
person.familyNameMonteiro Alfredo
person.familyNameHenriques
person.familyNameFontes Ribeiro
person.familyNameCruz
person.familyNameCabral
person.familyNameMonteiro Martins Minas da Piedade
person.familyNameRobalo
person.familyNameCenteio Matafome
person.givenNameSara
person.givenNameTamaeh
person.givenNameRita
person.givenNameCarlos Alberto
person.givenNameMaria Teresa
person.givenNameCélia
person.givenNameMaria de Fátima
person.givenNameMaria Paula
person.givenNamePaulo Nuno
person.identifierRibeiro
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person.identifier.ciencia-idA81A-36ED-5A22
person.identifier.ciencia-idE11C-A704-9C18
person.identifier.ciencia-id0413-7328-BD68
person.identifier.orcid0000-0002-0423-7959
person.identifier.orcid0000-0001-5514-0797
person.identifier.orcid0000-0003-4650-1081
person.identifier.orcid0000-0002-9707-4895
person.identifier.orcid0000-0001-9846-6754
person.identifier.orcid0000-0003-4562-6683
person.identifier.orcid0000-0002-5335-8810
person.identifier.orcid0000-0002-8200-6910
person.identifier.orcid0000-0002-3422-290X
person.identifier.ridB-2002-2012
person.identifier.scopus-author-id57189592328
person.identifier.scopus-author-idFontes Ribeiro
person.identifier.scopus-author-id7201363895
person.identifier.scopus-author-id25222407900
person.identifier.scopus-author-id9269662100
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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