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Bacterial cellulose: a versatile biopolymer for wound dressing applications

2019-07Journal article Restricted access
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dc.contributor.authorPortela, Raquel
dc.contributor.authorR. Leal, Catarina
dc.contributor.authorAlmeida, Pedro L.
dc.contributor.authorSobral, Rita
dc.date.accessioned2019-07-19T13:52:19Z
dc.date.available2019-07-19T13:52:19Z
dc.date.issued2019-07
dc.description.abstractAlthough several therapeutic approaches are available for wound and burn treatment and much progress has been made in this area, room for improvement still exists, driven by the urgent need of better strategies to accelerate wound healing and recovery, mostly for cases of severe burned patients. Bacterial cellulose (BC) is a biopolymer produced by bacteria with several advantages over vegetal cellulose, such as purity, high porosity, permeability to liquid and gases, elevated water uptake capacity and mechanical robustness. Besides its biocompatibility, BC can be modified in order to acquire antibacterial response and possible local drug delivery features. Due to its intrinsic versatility, BC is the perfect example of a biotechnological response to a clinical problem. In this review, we assess the BC main features and emphasis is given to a specific biomedical application: wound dressings. The production process and the physical-chemical properties that entitle this material to be used as wound dressing namely for burn healing are highlighted. An overview of the most common BC composites and their enhanced properties, in particular physical and biological, is provided, including the different production processes. A particular focus is given to the biochemistry and genetic manipulation of BC. A summary of the current marketed BC-based wound dressing products is presented, and finally, future perspectives for the usage of BC as wound dressing are foreseen.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPORTELA, Raquel; [et al] – Bacterial cellulose: a versatile biopolymer for wound dressing applications. Microbial Biotechnology. ISSN 1751-7915. Vol. 12, N.º 4 (2019), pp. 586-610 (SI)pt_PT
dc.identifier.doi10.1111/1751-7915.13392pt_PT
dc.identifier.issn1751-7915
dc.identifier.urihttp://hdl.handle.net/10400.21/10342
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationPOCI-01-0145-FEDER-007688 - FEDER funds through the COMPETE 2020 Programpt_PT
dc.relationUID/Multi/04378/2019 - Unidade de Ciências Biomoleculares Aplicadas - UCIBIOpt_PT
dc.relationPOCI-01-0145-FEDER-07728 - FEDER funds through PT2020 Partnership Agreementpt_PT
dc.relationFighting Staphylococcus aureus - Peptidoglycan amidation as a new target
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/pdf/10.1111/1751-7915.13392pt_PT
dc.subjectWoundpt_PT
dc.subjectBurn treatmentpt_PT
dc.subjectBacterial cellulose (BC)pt_PT
dc.subjectBiocompatibilitypt_PT
dc.titleBacterial cellulose: a versatile biopolymer for wound dressing applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFighting Staphylococcus aureus - Peptidoglycan amidation as a new target
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FCTM%2F50025%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FFIS-NAN%2F0117%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIC%2F31645%2F2017/PT
oaire.citation.endPage610pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage586pt_PT
oaire.citation.titleMicrobial Biotechnologypt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNamePortela
person.familyNameMarques Mendes Almeida da Rosa Leal
person.familyNameMarques de Almeida
person.familyNameSobral
person.givenNameRaquel
person.givenNameCatarina
person.givenNamePedro
person.givenNameRita
person.identifierA-2814-2009
person.identifier.ciencia-id1813-219B-DD6E
person.identifier.ciencia-idAF15-486E-BB15
person.identifier.ciencia-id0218-71B2-2DE0
person.identifier.ciencia-id7F1F-7412-A2C3
person.identifier.orcid0000-0002-5559-9554
person.identifier.orcid0000-0001-5871-4936
person.identifier.orcid0000-0001-7356-8455
person.identifier.orcid0000-0003-4533-7531
person.identifier.ridB-4356-2009
person.identifier.ridH-4710-2011
person.identifier.scopus-author-id57201234562
person.identifier.scopus-author-id7005379280
person.identifier.scopus-author-id57190384213
person.identifier.scopus-author-id6507285825
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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