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"In-vitro" corrosion behaviour of the magnesium alloy with Al and Zn (AZ31) protected with a biodegradable polycaprolactone coating loaded with hydroxyapatite and cephalexin

2015-10-10Journal article Restricted access
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dc.contributor.authorZomorodian, A.
dc.contributor.authorSantos, Catarina
dc.contributor.authorCarmezim, M. J.
dc.contributor.authorSilva, Maria Teresa Oliveira de Moura e
dc.contributor.authorFernandes, João C. S.
dc.contributor.authorMontemor, Maria de Fátima
dc.date.accessioned2016-03-08T12:35:46Z
dc.date.available2016-03-08T12:35:46Z
dc.date.issued2015-10-10
dc.description.abstractMg alloys are very susceptible to corrosion in physiological media. This behaviour limits its widespread use in biomedical applications as bioresorbable implants, but it can be controlled by applying protective coatings. On one hand, coatings must delay and control the degradation process of the bare alloy and, on the other hand, they must be functional and biocompatible. In this study a biocompatible polycaprolactone (PCL) coating was functionalised with nano hydroxyapatite (HA) particles for enhanced biocompatibility and with an antibiotic, cephalexin, for anti-bacterial purposes and applied on the AZ31 alloy. The chemical composition and the surface morphology of the coated samples, before and after the corrosion tests, were studied by scanning electron microscopy (SEM) coupled with energy dispersive x-ray analysis (EDX) and Raman. The results showed that the presence of additives induced the formation of agglomerates and defects in the coating that resulted in the formation of pores during immersion in Hanks' solution. The corrosion resistance of the coated samples was studied in Hank's solution by electrochemical impedance spectroscopy (EIS). The results evidenced that all the coatings can provide corrosion protection of the bare alloy. However, in the presence of the additives, corrosion protection decreased. The wetting behaviour of the coating was evaluated by the static contact angle method and it was found that the presence of both hydroxyapatite and cephalexin increased the hydrophilic behaviour of the surface. The results showed that it is possible to tailor a composite coating that can store an antibiotic and nano hydroxyapatite particles, while allowing to control the in-vitro corrosion degradation of the bioresorbable Mg alloy AZ31. (C) 2015 Elsevier Ltd. All rights reserved.pt_PT
dc.identifier.citationZOMORODIAN, A.; [et al.] - "In-vitro" corrosion behaviour of the magnesium alloy with Al and Zn (AZ31) protected with a biodegradable polycaprolactone coating loaded with hydroxyapatite and cephalexin. Electrochimica Acta. ISSN. 0013-4686. Vol. 179 (2015), pp. 431-440pt_PT
dc.identifier.doi10.1016/j.electacta.2015.04.013pt_PT
dc.identifier.issn0013-4686
dc.identifier.issn1873-3859
dc.identifier.urihttp://hdl.handle.net/10400.21/5800
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPergamon-Elsevier Science LTDpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0013468615008919pt_PT
dc.subjectFunctional biocoatingpt_PT
dc.subjectBioresorbable magnesiumpt_PT
dc.subjectCorrosionpt_PT
dc.subjectHydroxyapatitept_PT
dc.title"In-vitro" corrosion behaviour of the magnesium alloy with Al and Zn (AZ31) protected with a biodegradable polycaprolactone coating loaded with hydroxyapatite and cephalexinpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage440pt_PT
oaire.citation.startPage431pt_PT
oaire.citation.volume179pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT

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