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Metformin in SARS-CoV-2 infection: a hidden path - from altered inflammation to reduced mortality (a review from the literature)

2023-01Journal article Open access
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dc.contributor.authorPedrosa, Ana Realista
dc.contributor.authorMartins, Diana Cruz
dc.contributor.authorRizzo, Manfredi
dc.contributor.authorSilva-Nunes, José
dc.date.accessioned2023-02-14T15:30:46Z
dc.date.available2023-02-14T15:30:46Z
dc.date.issued2023-01
dc.description.abstractSARS-CoV-2 infection has been a major threat to human health and a huge challenge to Medicine. In only two years, COVID-19 affected >350 million people, causing >5.6 million deaths. Chronic inflammatory states, such as diabetes or obesity, are known risk factors for COVID-19 poorest outcomes, with a higher risk for disease severity and greater mortality. Metformin remains on the first line of the management of hyperglycemia in type 2 diabetes. Through its anti-inflammatory and immunomodulatory mechanisms, metformin appears as an opportunity to control the dysregulated cytokine storm secondary to SARS-CoV-2 infection. Recent studies point towards a potential protective role of metformin in the course of COVID-19, showing that current or previous treatment with metformin associates with better outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPedrosa AR, Martins DC, Rizzo M, Silva-Nunes J. Metformin in SARS-CoV-2 infection: a hidden path - from altered inflammation to reduced mortality (a review from the literature). J Diabetes Complications. 2023;37(2):108391. [Online ahead of print].pt_PT
dc.identifier.doi10.1016/j.jdiacomp.2022.108391pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15582
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1056872722003038pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectDiabetespt_PT
dc.subjectMetforminpt_PT
dc.subjectMortalitypt_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectSeveritypt_PT
dc.titleMetformin in SARS-CoV-2 infection: a hidden path - from altered inflammation to reduced mortality (a review from the literature)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage108391pt_PT
oaire.citation.titleJournal of Diabetes and its Complicationspt_PT
oaire.citation.volume37pt_PT
person.familyNameSilva-Nunes
person.givenNameJosé António
person.identifier.ciencia-id4B1C-E132-25F0
person.identifier.orcid0000-0002-4728-1220
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9352b380-9661-4316-ab88-6ed9be1020ac
relation.isAuthorOfPublication.latestForDiscovery9352b380-9661-4316-ab88-6ed9be1020ac

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