Repository logo
 
Publication

Tobacco smoking have no influence on buccal telomere length among Portuguese master students

2019-10Conference object Open access
Simple item page
dc.contributor.authorBrito, Miguel
dc.contributor.authorAzevedo, Patrícia
dc.contributor.authorCoelho, André
dc.contributor.authorVeiga, Luisa
dc.contributor.authorCosta-Veiga, Ana
dc.date.accessioned2020-03-05T18:55:38Z
dc.date.available2020-03-05T18:55:38Z
dc.date.issued2019-10
dc.descriptionIPL/2018/SCITelomer_ESTeSLpt_PT
dc.description.abstractIn Portugal, the average age of starting tobacco consumption is around 16 years, with an increase in consumption in recent years. The use of tobacco is a risk factor for age-related diseases, being one of the main causes of death and a risk factor for several chronic diseases, including diseases of the cardiovascular system, diabetes, and cancer. Different studies have shown a clear relationship between tobacco smoking and oxidative stress, which is one of the factors that accelerate the shortening of telomeres. The aim of this study was to evaluate the effect of tobacco smoking on the relative length of telomers in master students as a biomarker of health status. A cross-sectional study was performed by assessing relative Telomere Length (TL) in 131 master students. TL was evaluated from buccal swabs in 44 males and 89 females (aged between 18 and 52 years, mean 26.4) by multiplex quantitative Polymerase Chain Reaction (PCR). This technique consists in determining the relative ratio (T/S) between the telomere region copy number (T) and a single copy gene (S), albumin gene, using a relative standard curve. Mann-Whitney tests were used to detect TL differences between smokers and non-smokers and addiction levels (Light vs Moderate or Heavy). Statistical analysis was adjusted for age, sex, and BMI. Age and TL were negatively correlated as expected (Spearman Rho=-1.66, p=0.080). There were no statistically significant differences in TL between smokers and non-smokers, addiction levels or gender (Mann-Whitney tests, p>0.10). A negative association between buccal TL and tobacco smoking was not confirmed. One possible explanation can be the high turnover rate in buccal exfoliate cells relative to other cells such as lymphocytes. Although the association has not been signed with TL, the negative effect of tobacco consumption on the risk of cancer risk and respiratory alterations is largely confirmed. Future studies should include a higher number of participants. Although buccal exfoliate cells is a less invasive method, TL can be more specific using lymphocytes cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBrito M, Azevedo P, Coelho A, Veiga L, Costa-Veiga A. Tobacco smoking have no influence on buccal telomere length among Portuguese master students. In: ASHG 2019 – Annual Meeting of the American Society of Human Genetics, Houston-TX (USA), October 15-19.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/11207
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationIPL/2018/SCITelomer_ESTeSLpt_PT
dc.relation.publisherversionhttps://www.ashg.org/wp-content/uploads/2019/10/ASHG-2019-poster-abstracts.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectTobacco consumptionpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectTelomerspt_PT
dc.subjectMaster studentspt_PT
dc.subjectPortugalpt_PT
dc.subjectIPL/2018/SCITelomer_ESTeSLpt_PT
dc.titleTobacco smoking have no influence on buccal telomere length among Portuguese master studentspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceHoustonpt_PT
person.familyNameBrito
person.familyNameVeiga
person.givenNameMiguel
person.givenNameLuisa
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id9413-918D-DB0E
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0003-1153-8343
person.identifier.ridA-7970-2016
person.identifier.ridL-2730-2013
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id8318978600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublicationaac1914a-275f-4be2-819d-ab41d356b45a
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Tobacco smoking have no influence on buccal telomere length among Portuguese master students.pdf
Size:
697.46 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Posters