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Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells

2014-11Journal article Restricted access
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dc.contributor.authorSedlacek, Jindrich
dc.contributor.authorMartins, Luisa
dc.contributor.authorDanek, Petr
dc.contributor.authorPombeiro, Armando
dc.contributor.authorCvek, Boris
dc.date.accessioned2015-08-24T10:59:23Z
dc.date.available2015-08-24T10:59:23Z
dc.date.issued2014-11
dc.description.abstractDiethyldithiocarbamate (ditiocarb), a metabolite of the old anti-alcoholic drug disulfiram (Antabuse), forms proteasome-inhibiting metal complexes with copper or zinc that suppress cancer cells both in vitro and in vivo. The drug has been used in a clinical trial (NCT00742911) along with copper gluconate as a dietary supplement in patients with cancer spreading to the liver. In this study, we demonstrate the effect of synthetic complexes of disulfiram with four various metals (Mn, Fe, Cr and Cu) used as food supplements. These complexes may be spontaneously formed in the blood during the use of disulfiram with divalent metals and thus may suppress the growth of cancer in vivo. The cytotoxic effect of the compounds and the compounds' ability to inhibit the cellular proteasome were tested in the osteosarcoma cell line U2OS. After 48 h, copper and manganese complexes exhibited cytotoxic effect on the cell line, in sharp contrast to both iron and chromium complexes. (C) 2014 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.por
dc.identifier.citationSEDLACEK, Jindrich; [et al] – Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells. Journal of Applied Biomedicine. ISSN: 1214-021X. Vol. 12, n.º 4 (2014), pp. 301-308por
dc.identifier.doi10.1016/j.jab.2014.04.002
dc.identifier.issn1214-021X
dc.identifier.issn1214-0287
dc.identifier.urihttp://hdl.handle.net/10400.21/4934
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherUniversity South Bohemiapor
dc.subjectDisulfirampor
dc.subjectDietary supplementspor
dc.subjectDithiocarbamate-metalpor
dc.subjectCancerpor
dc.subjectProteasomepor
dc.subjectCopperpor
dc.subjectManganesepor
dc.titleDiethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cellspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceCeska Budejovicepor
oaire.citation.endPage308por
oaire.citation.issue4por
oaire.citation.startPage301por
oaire.citation.titleJournal of Applied Biomedicinepor
oaire.citation.volume12por
person.familyNameSedlacek
person.familyNameMartins
person.familyNameDanek
person.familyNamePombeiro
person.familyNameCvek
person.givenNameJindrich
person.givenNameLuisa
person.givenNamePetr
person.givenNameArmando
person.givenNameBoris
person.identifier637885
person.identifier.ciencia-idE218-E297-A4EA
person.identifier.ciencia-id8311-38FA-CEFB
person.identifier.orcid0000-0003-1096-6434
person.identifier.orcid0000-0002-5403-9352
person.identifier.orcid0000-0002-6552-2219
person.identifier.orcid0000-0001-8323-888X
person.identifier.orcid0000-0001-8238-3890
person.identifier.ridG-6210-2011
person.identifier.ridW-2475-2017
person.identifier.ridI-5945-2012
person.identifier.scopus-author-id8650947800
person.identifier.scopus-author-id57193270091
person.identifier.scopus-author-id7006067269
rcaap.rightsclosedAccesspor
rcaap.typearticlepor
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