Browsing by Issue Date, starting with "2023-02-16"
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- Synthesis and the in vitro evaluation of antitumor activity of novel thiobenzanilidesPublication . Álvaro Martins, Maria Joao; Railean, Violeta; Martins, Filomena; Machuqueiro, Miguel; Pacheco, Rita; Santos, SusanaCancer is a generic term for a large group of diseases that are the second-leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. Melanoma is a highly aggressive skin tumor with an increasing incidence and poor prognosis in the metastatic stage. Breast cancer still stands as one of the major cancer-associated deaths among women, and diagnosed cases are increasing year after year worldwide. Despite the recent therapeutic advances for this type of cancer, novel drugs and treatment strategies are still urgently needed. In this paper, the synthesis of 18 thiobenzanilide derivatives (17 of them new) is described, and their cytotoxic potential against melanoma cells (A375) and hormone-dependent breast cancer (MCF-7) cells is evaluated using the MTT assay. In the A375 cell line, most of the tested thiobenzanilides derivatives showed EC50 values in the order of mu M. Compound 17 was the most promising, with an EC50 (24 h) of 11.8 mu M. Compounds 8 and 9 are also interesting compounds that deserve to be further improved. The MCF-7 cell line, on the other hand, was seen to be less susceptible to these thiobenzanilides indicating that these compounds show different selectivity towards skin and breast cancer cells. Compound 15 showed the highest cytotoxic potential for MCF-7 cells, with an EC50 (24 h) of 43 mu M, a value within the range of the EC50 value determined for tamoxifen (30.0 mu M). ADME predictions confirm the potential of the best compounds. Overall, this work discloses a new set of thiobenzanilides that are worth being considered as new scaffolds for the further development of anticancer agents.
- A new approach for agile teams' allocation in open innovation projectsPublication . Anes, Vitor; Abreu, António; Dias, Ana; Calado, João Manuel FerreiraDue to constant change in the marketplace, it can be difficult for companies to secure the material, human, and technological resources necessary for competitive innovation activities. In this sense, and to overcome these constraints, the open innovation model is a quite successful approach, where the sharing of resources among companies allows the formation of an innovation ecosystem. However, the execution time of these projects can be negatively affected if the performance of each work team is not taken into account. In this work, the application of the agile approach in open innovation projects is proposed as a way to reduce the uncertainty both in the execution time of the projects and in the respective implementation costs. In this sense, a methodology for optimal team assignment for agile teams in open innovation projects according to their performance on each project task is developed to determine the optimal team assignment that leads to the shortest project execution time. This methodology will support decision making in the project management of open innovation projects, especially in the selection of the internal and external work teams that will participate in a given innovation project. The application of the proposed methodology is illustrated with an example describing and analyzing the different steps of its application. The results show that with the proposed methodology it is possible to take into account the performance of each team when calculating the project execution time and that the project execution time varies depending on the assignment of the agile teams to the project tasks. It is also shown that it is possible to determine the optimal assignment with the shortest project execution time.
- Attitudinal and behavioural differences towards farm animal welfare among consumers in the BRIC countries and the USAPublication . Mata, F.; Dos Santos, Maria José Palma Lampreia; Cocksedge, JackThis study explores cross-cultural differences in consumers’ attitudes toward farm animal welfare (FAW) in BRIC countries. Questionnaires administered in each country contained the following questions: (i) “It is important to me that animals used for food are well cared for”, (ii) “The typical nationality thinks it is important that animals used for food are well cared for”, (iii) “Low meat prices are more important than the well-being of animals used for food”, and (iv) “The typical nationality thinks that low meat prices are more important than the well-being of animals used for food”. Answers were given on a Likert scale (from total disagreement to total agreement). Data fit multinomial logistic models using “Country” and “Gender” as factors and “Age” as a covariate. The results showed that women had stronger pro-animal attitudes. Statements on the perception of FAW importance had an agreement tendency that increased with age, while the opposite was true for meat prices. Brazil showed the highest levels of individual pro-FAW attitudes, and the same trend in relation to meat prices. Russia showed a slightly lower pro-FAW attitude, but the perception of the compatriots’ attitudes towards FAW showed the opposite. Russians in general disagree with low meat prices in exchange for the detriment of FAW. Indians were the least supportive of FAW and, together with the Chinese, were the least supportive of an increase in meat prices to improve FAW. The Chinese showed prominent levels of neutrality towards FAW. These results may contribute to the definition of food and trade policies and help to adjust the supply chain to consumers’ socio-cultural and economic differences.