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  • Paramiloidose, transplante hepático e força muscular: qual a relação?
    Publication . Tomás, Maria Teresa; Freire, Amtónio; Morbey, A.; Veloso, J.; Monteiro, Estela; Barroso, Eduardo
    Paramiloidose - Doença hereditária autossómica dominante, de evolução crónica e progressiva, envolve predominantemente os membros inferiores, conduzindo à diminuição da força muscular e da sensibilidade e ao compromisso da marcha. Objectivos do estudo: 1. Avaliar os níveis de força máxima do quadricípete em sujeitos submetidos a transplante hepático (TH) por PAF, antes do TH, à data da alta, 3 meses após o TH, 6 meses após o TH, 1 ano após o TH; 2. Comprovar quantitativamente a eventual recuperação da força muscular; 3. Inferir os benefícios de actividade física/estilos de vida mais activos no pós-TH de doentes com PAF.
    2003-05Documento de conferência Acesso aberto Ver mais
  • Effects of a sub-lethal copper exposure on non-green Acer pseudoplatanus cell lipids
    Publication . Pádua, Mário; Aubert, Serge; Casimiro, Adalcina; Bligny, Richard; Block, Maryse A
    Non-green sycamore cells (Acer pseudoplatanus L.) treated with 50 μM Cu2+ showed a reversible arrest of cell growth after 5 d, indicating that the concentration used was sub-lethal for the cells. Growth arrest was accompanied by hexose and nucleotide-phosphate accumulation and, in contrast with previous reports, no polar-lipid degradation was found. Sub-lethal Cu2+ exposure resulted in an increase in phospholipid amounts, mostly due to an increase of phosphatidylethanolamine. Although the total amount of glycolipids was not significantly changed, Cu2+ exposure changed the relative concentrations of monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and sulphoquinovosyldiacylglycerol (SQDG). There was a marked increase of DGDG whereas MGDG and SQDG declined. Our results suggest an increase of DGDG synthesis through a pathway similar to the recently described DGD2 pathway and an inhibition of SQDG synthesis. Furthermore, we observed modifications of the fatty acid composition of the plastid synthesized lipids. A significant increase in linoleate (18:2) and a decrease in linolenate (18:3) were found in MGDG, DGDG, SQDG and phosphatidylglycerol (PG), reflecting a deficient desaturation of plastid-located 18:2 fatty acids. In SQDG and PG, Cu2+ treatment also induced a strong enrichment of palmitate (16:0). The effects of Cu2+ on DGDG synthesis and fatty acid desaturation are discussed.
    2003-05Artigo científico Acesso aberto Ver mais