Browsing by Author "Veiga, Joaquim"
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- TBCCD1 and OFD1, a novel centrosomal protein partnership with a role in human ciliopathies?Publication . Veiga, Joaquim; Carmona, Bruno; Camelo, Carolina; Pereira, Dulce; Marinho, H. Susana; Soares, HelenaCilia are hair-like appendages, consisting of a microtubule (MT)-based ciliary axoneme, that fulfill critical motility and sensory functions required for normal embryonic development and also for homeostasis of adult tissues. At their base, cilia have a centriole/basal body, which can be derived from the centrosome, and that nucleates the ciliary axoneme (primary cilia). Centrosomes consist of a pair of centrioles surrounded by the pericentriolar matrix that nucleate/organize the cytoskeleton and are implicated in cell migration, adhesion and polarity, while in mitosis they assist spindle pole formation.