Percorrer por autor "Santos, Pedro"
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- Criação e desenvolvimento de novos produtosPublication . Santos, Pedro; Damião, JoséEsta dissertação final, elaborada no âmbito da parte não escolar do Mestrado em Gestão e Empreendedorismo pelo Instituto Superior de Contabilidade e Administração de Lisboa, aborda o tema «New Product Development». Como é do conhecimento de muitos discentes das ciências económicas, esta é uma área em grande expansão ao longo dos últimos anos. Para aprofundar este tema, temos que o estudar como um processo que engloba várias outras vertentes e, como tal, esta dissertação faz um levantamento da literatura académica sobre os assuntos mais importantes relacionados com o lançamento de um novo produto. Ao longo deste trabalho, irão ser discutidos temas como o ciclo de vida de um produto e o Marketing, relacionando estes mesmos com a estratégia ideal para cada situação ou produto. É de grande importância analisar também modelos como o Business Model Canvas de Osterwalder, modelo este que nos ajuda a conciliar os diversos aspectos a ter em conta na criação e desenvolvimento de um produto. Além dos já referidos, este trabalho dedica-se também a outros tópicos de grande importância para o empreendedorismo, como o estudo dos ambientes interno e externo (através de diversas análises), a nova tendência de co-criação de valor e a utilização de business plans e balanced scorecards. Foram também realizadas entrevistas a diversas pessoas envolvidas profissionalmente na criação e/ou desenvolvimento de produtos, de forma a retirar conclusões pertinentes sobre o tema em questão.
- Improvement of DC microgrid voltage regulation based on bidirectional intelligent charging systemsPublication . Santos, Pedro; Fonte, Pedro M; Luís, RicardoIn several cities, there are existing DC tram/subway grids. These existing grids in some cases cover a big part of the city and create the opportunity to install EV charging infrastructures. Such implementation could be built in order to contribute to the DC grid stability, enhancing the DC grid voltage regulation, through vehicle-to-tram concept. This can be reached with bidirectional DC/DC converters which enable energy transfer from vehicles to the DC grid to support such starts. Hereafter, the energy may flow normally from the grid to the vehicles. However, these improvements come with certain challenges in terms of power conversion, voltage regulation, grid coordination and intelligence. This paper defines the design principles of a tram DC-microgrid, which enables fast-charging, supported by fuzzy controllers that follow dynamically the overhead line voltages and the charging/discharging conditions of the proposed EV charging infrastructure. A discussion and conclusion about the practical applicability of the tram DC microgrid and its the complementarity with the EV charging infrastructure are demonstrated evaluating the results of DCmicrogrid voltage regulation with the proposed methodology.
- MALDI-TOF MS biomarkers for methicillin-resistant Staphylococcus aureus detection: a systematic reviewPublication . Santos, Pedro; Alho, Irina; Ribeiro, EdnaBackground/objectives: Methicillin-resistant Staphylococcus aureus (MRSA) infections remain a significant challenge in healthcare. Conventional and molecular techniques used for MRSA identification are either time-consuming or costly. Alternatively, Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF MS) offers a rapid method for microbial identification and has the potential to detect biomarkers that distinguish methicillin resistance in S. aureus isolates. This study aimed to identify methicillin-resistant discriminative biomarkers for S. aureus obtained using MALDI-TOF MS. Methods: A systematic review was conducted by searching databases such as PubMed and Web of Science for studies that focused on MRSA detection with biomarkers by MALDI-TOF MS, including all relevant studies published up to July 2024. The review protocol was registered in the PROSPERO registry. Results: A total of 15 studies were selected for analysis. Data were extracted on study location, sample size, MALDI-TOF MS analyzer, sample preparation, methicillin resistance and sensitivity biomarkers, and the use of Artificial Intelligence (AI) models. Notably, PSM-mec and delta toxin were frequently reported as informative biomarkers, detectable at 2414 ± 2 Da and 3006 ± 2 Da, respectively. Additionally, eight studies used AI models to identify specific biomarkers differentiating methicillin-resistant and methicillin-sensitive strains, based on differences in peak intensities or the exclusive presence of certain peaks. Moreover, two studies employed the detection of MRSA in low concentrations from biological samples, and others employed an optimized matrix solution for improved analysis. Conclusions: Overall, MALDI-TOF MS is not only a powerful tool for the identification of bacterial isolates but also shows strong potential for rapid, cost-effective detection of methicillin resistance in S. aureus through biomarker analysis. Given that it is already implemented in several clinical laboratories, this approach could be adopted without a high additional cost.