Browsing by Author "Pinto, Ines Figueiredo"
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- Vagus nerve stimulation for the management of immune-mediated inflammatory diseasesPublication . Tarn, Jessica; Pinto, Ines Figueiredo; Ng, Wan-Fai; Staats, P. S.; Ayata, C.; Abd-Elsayed, A.The vagus nerve is a key component of several homeostatic axes including the cholinergic antiinflammatory pathway, hypothalamic–pituitary-adrenergic axis, and the brain-gut axis, all of which play important roles in the regulation of the immune system. Autonomic dysfunction has been described in many immune-mediated inflammatory diseases (IMIDs). In addition, several pilot studies have shown that vagus nerve stimulation leads to improvement in several IMIDs. Taken together, the vagus nerve is a promising novel therapeutic target for the management of IMIDs.