Browsing by Author "Lopes, Susana Isabel"
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- PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature reviewPublication . Lopes, Susana Isabel; Ferreira, Sara; Caetano, MarcoIntroduction: PET/CT combines the molecular with the anatomical level which, with the administration of a hypoxia-sensitive radiopharmaceutical, allows the evaluation of tissue oxygenation. Materials and Methods: The work consists of a systematic literature review, including electronic addresses, books, and articles dating from July 1997 to December 2019. The aim of this work is to identify the best-suited PET radiopharmaceuticals for the detection of cell hypoxia and recognize the benefits for treatment planning with IMRT/VMAT techniques. Results: Hypoxia affects the likelihood of cure of head and neck tumors, thereby reducing the success rate. Radiopharmaceuticals such as 18F-FMISO, 18F-FETNIM, and 18F-HX4 allow the delineation of hypoxic subvolumes within the target volume to optimize IMRT/VMAT treatment. Discussion: The identification of hypoxia areas with PET/CT imaging and subsequent treatment with IMRT/VMAT allows a possible radiation dose escalation in radioresistant subvolumes. Conclusion: There is a decrease in relapses and an increased likelihood of disease-free survival.