Percorrer por autor "Franco, Nuno H."
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- A call for preregistration of in vitro research: pregistration as a tool to improve reproducibility and transparencyPublication . Heinl, Céline; Franco, Nuno H.; Bert, Bettina; Siewert, Katherina; Movia, Dania; Aruçi, Edlira; Ladeira, Carina; Sanin, Ahmed Y.; Neuhaus, Winfried; Kahlert, Ulf D.; Ghosh, Manosij; Thomas, Aurélie; Sotiropoulos, AthanassiaBiomedical research, like any other research field, is vulnerable to problems in its planning, execution, documentation, analysis, interpretation, and reporting. These issues can impede the reproducibility of research findings and hinder translation into clinical practice. In addition, there is growing societal pressure to hasten the shift to animal-free research methods. To alleviate the ethical dilemma of using animals in research, the 3Rs principle (replace, reduce, refine) calls for reducing or replacing such experiments wherever possible. Nevertheless, scientific and biomedical research, as well as safeguarding human and environmental health, continue to depend on animal experiments. To apply the 3Rs principles without compromising scientific progress and safety standards, it is imperative to ensure that in vitro methods to replace animal experiments are robust and reliable.