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Percorrer por autor "Ferretti, Francesco"

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  • Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymers
    Publication . Sutradhar, Manas; Alegria, Elisabete; Ferretti, Francesco; Raposo, Luís R; Guedes Da Silva, M. Fátima C.; Baptista, Pedro; Fernandes, Alexandra; Pombeiro, Armando
    The syntheses of the heterometallic sodium and potassium-dioxidovanadium 2D polymers, [NaVO2(1 kappa NOO';2 kappa O ''-L)(H2O)](n), (1) and [KVO2(1 kappa NOO';2 kappa O';3 kappa O ''-L)(EtOH)](n) (2) (where the kappa notation indicates the coordinating atoms of the polydentate ligand L) derived from (3,5-di-tert-butyl-2-hydroxybenzylidene)-2-hydroxybenzohydrazide (H2L) are reported. The polymers were characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction analysis. The antiproliferative potential of 1 and 2 was examined towards four human cancer cell lines (ovarian carcinoma, A2780, colorectal carcinoma, HCT116, prostate carcinoma, PC3 and breast adenocarcinoma, MCF-7cell lines) and normal human fibroblasts. Complex 1 and 2 showed the highest cytotoxic activity against A2780 cell line (IC50 8.2 and 11.3 mu M, respectively) with 1 > 2 and an IC50 in the same range as cisplatin (IC50 3.4 mu M; obtained in the same experimental conditions) but, interestingly, with no cytotoxicity to healthy human fibroblasts for concentrations up to 75 mu M. This high cytotoxicity of 1 in ovarian cancer cells and its low cytotoxicity in healthy cells demonstrates its potential for further biological studies. Our results suggest that both complexes induce ovarian carcinoma cell death via apoptosis and autophagy, but autophagy is the main biological cause of the reduction of viability observed and that ROS (reactive oxygen species) may play an important role in triggering cell death.
    2019-11Artigo científico Acesso restrito Ver mais
  • Synergistic catalytic action of vanadia-titania composites towards the microwave-assisted benzoin oxidation
    Publication . Ferretti, Francesco; Da Costa Ribeiro, Ana Paula; Alegria, Elisabete; Ferraria, Ana Maria; Kopylovich, Maximilian; Guedes Da Silva, M. Fátima C.; Marchetti, Fabio; Pombeiro, Armando
    Intensification of chemical processes according to the motto "faster, simpler, greener" is among the main concerns nowadays. One of the ways of intensification is the application of synergistic catalytic effects when the overall efficiency of a composite catalyst is much higher than the sum of the component activities. Here, we report on the preparation of synergistic catalytic materials by a simple and straightforward ball milling procedure. Oxidation of benzoin was selected as a model reaction to demonstrate the viability of the concept. For the V2O5-TiO2 (95 : 5) composite material, the synergistic effect is triggered by low power microwave irradiation with more than a tenfold jump in the catalytic activity in comparison to the activities of the individual components.
    2019-03-14Artigo científico Acesso restrito Ver mais