Percorrer por autor "Costea, Daniela Elena"
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- Establishing standard operating procedures for isolation, characterizing and preservation of cells from oral potentially malignant disorders: a concept project proposalPublication . Costea, Daniela Elena; Ladeira, Carina; Vandis, Vera; Kozlakidis, ZisisStandard operating procedures (SOP) are crucial for the isolation, characterization, and biobanking of cells from tissues due to several key reasons: consistency and reproducibility, quality control, data integrity and Traceability, safety and ethics, resource efficiency, cross-training and knowledge transfer, regulatory compliance, publication and collaboration, and long-term research. This project aims to establish standard operating procedures (SOP) for isolating, characterizing, and biobanking cells from oral potentially malignant disorders (OPMDs).
- Establishment of a standardized biological sample collection protocol for OPMDsPublication . Jiaao, Yu; Ladeira, Carina; Van Dis, Vera; Costea, Daniela Elena; Villar, Stephanie; Kozlakidis, ZisisThere has been a growing number of clinical studies on OPMDs in recent years, reflecting increasing interest in this field. Among these studies, EU countries have the second-highest number of publications after China. According to a meta-analysis, the prevalence of OPMDs is approximately 3.07%. While surgical diagnosis remains the gold standard, there is currently no standardized protocol for the surgical biopsy of oral lesions. To reach a protocol compendium for the collection of oral biological samples, a literature review on clinical studies with detailed methodologies of surgical biopsy of OPMDs in clinical settings was performed.
- The INTERCEPTOR working group 5 on biobanking aspects for biological tissues from oral potentially malignant disordersPublication . Costea, Daniela Elena; Ladeira, Carina; Vandis, Vera; Kozlakidis, ZisisStandard operating procedures (SOP) are crucial for the isolation, characterization, and biobanking of cells from tissues. However, some challenges persist in OPMDs. The following will be discussed as part of the Working Group 5 (WG5) activities: biological heterogeneity, methodological heterogeneity, data integrity and Traceability, and supporting precision medicine research. Purpose: One of the main aims of the Interceptor grant working group 5 is to evaluate and prioritize researcher needs on biobanking aspects for biological tissues from Oral Potentially Malignant Disorders (OPMDs). To this end, the networking and exchange of ideas and expertise would be encouraged, leading to a second stage towards a more formal evaluation of the biobanking priorities within the IMPD research and clinical fields.