Browsing by Author "Bruno, Paula Marta"
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- Body composition, muscle strength, functional capacity, and physical disability risk in liver transplanted familial amyloidotic polyneuropathy patientsPublication . Tomás, Maria Teresa; Santa-Clara, Helena; Monteiro, Estela; Baynard, Tracy; Carnero, Elvis; Bruno, Paula Marta; Barroso, Eduardo; Sardinha, Luís; Fernhall, BoAbstract: Background: Familial amyloidotic polyneuropathy (FAP) is a neurodegenerative disease leading to sensory and motor polyneuropathies, and functional limitations. Liver transplantation is the only treatment for FAP, requiring medication that negatively affects bone and muscle metabolism. The aim of this study was to compare body composition, levels of specific strength, level of physical disability risk, and functional capacity of transplanted FAP patients (FAPTx) with a group of healthy individuals (CON). Methods: A group of patients with 48 FAPTx (28 men, 20 women) was compared with 24 CON individuals (14 men, 10 women). Body composition was assessed by dual-energy X-ray absorptiometry, and total skeletal muscle mass (TBSMM) and skeletal muscle index (SMI) were calculated. Handgrip strength was measured for both hands as was isometric strength of quadriceps. Muscle quality (MQ) was ascertained by the ratio of strength to muscle mass. Functional capacity was assessed by the six-minute walk test. Results: Patients with FAPTx had significantly lower functional capacity, weight, body mass index, total fat mass, TBSMM, SMI, lean mass, muscle strength, MQ, and bone mineral density. Conclusion: Patients with FAPTx appear to be at particularly high risk of functional disability, suggesting an important role for an early and appropriately designed rehabilitation program.
- A importância da actividade física em pacientes submetidos a transplante hepático: estudo longitudinalPublication . Tomás, Maria Teresa; Santa-Clara, Helena; Monteiro, Estela; Bruno, Paula Marta; Barroso, Eduardo; Sardinha, LuísPolineuropatia Amiloidótica Familiar (PAF) é uma doença neurodegenerativa que conduz a polineuropatia motora e sensitiva e a limitações funcionais. O transplante de fígado é presentemente a única intervenção eficaz no retardar da evolução da PAF. Objectivos do estudo: verificar os efeitos de um período de 6 meses de destreino na composição corporal e capacidade funcional num grupo de pacientes PAF submetidos a transplante hepático e que previamente haviam participado num programa de exercício combinado com a duração de 6 meses.
- A supervised versus home-based program effects on liver transplanted familial amyloidotic polyneuropathy patients: walking, fatigue and quality of lifePublication . Tomás, Maria Teresa; Santa-Clara, Helena; Monteiro, Estela; Gil, João; Bruno, Paula Marta; Barroso, Eduardo; Sardinha, LuísFamilial amyloidotic polyneuropathy is a systemic deposition of amyloidal fibre mainly on peripheral nervous system (but also in other systems like heart, gastrointestinal tract, kidneys, etc) and mainly produced in the liver. Purpose of this study: to evaluate the effects of a six months exercise training program(supervised or home-based) on walking capacity, fatigue and health related quality of life (HRQL) on Familial Amyloidotic Polyneuropathy patients submitted to a liver transplant.
- A supervised versus home-based program effects on liver transplanted familial amyloidotic polyneuropathy patients: walking, fatigue and quality of lifePublication . Tomás, Maria Teresa; Monteiro, Estela; Gil, João; Bruno, Paula Marta; Barroso, Eduardo; Sardinha, Luís; Santa-Clara, HelenaPurpose: To evaluate the effects of a six months exercise training program on walking capacity, fatigue and health related quality of life (HRQL). Relevance: Familial amyloidotic polyneuropathy disease (FAP) is an autossomic neurodegenerative disease, related with systemic deposition of amyloidal fibre mainly on peripheral nervous system and mainly produced in the liver. FAP often results in severe functional limitations. Liver transplantation is used as the only therapy so far, that stop the progression of some aspects of this disease. Transplantation requires aggressive medication which impairs muscle metabolism and associated to surgery process and previous possible functional impairments, could lead to serious deconditioning. Reports of fatigue are common feature in transplanted patients. The effect of supervised or home-based exercise training programs in FAP patients after a liver transplant (FAPTX) is currently unknown.
- The impact of exercise training on liver transplanted familial amyloidotic polyneuropathy (FAP) patientsPublication . Tomás, Maria Teresa; Santa-Clara, Helena; Bruno, Paula Marta; Monteiro, Estela; Carrolo, Margarida; Barroso, Eduardo; Sardinha, Luís B.; Fernhall, BoLiver transplantation is nowadays the only effective answer to adjourn the outcome of functional limitations associated with familial amyloidotic polyneuropathy (FAP), a neurodegenerative disease characterized by sensory and motor polyneuropathies. Nevertheless, there is a detrimental impact associated with the after-surgery period on the fragile physical condition of these patients. Exercise training has been proven to be effective on reconditioning patients after transplantation. However, the effects of exercise training in liver transplanted FAP patients have not been scrutinized yet.