Browsing by Author "Bettencourt, Ana F."
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- In vitro cytocompatibility evaluation of poly(DL-lactic acid) scaffolds loaded with minocycline and voriconazole addressing osteomyelitisPublication . Zegre, Miguel; Gonçalves, Lídia M.; Caetano, Liliana Aranha; Bettencourt, Ana F.Purpose: In this work is proposed the cytocompatibility evaluation of an innovative system based on the dual delivery of minocycline (Min) and voriconazole (Vor), aiming for bone infection therapeutics.
- Poly(DL-lactic acid) scaffolds adsorbed with minocycline and voriconazole: a new pathway towards infection containmentPublication . Zegre, Miguel; Henriques, M.; Santos, C.; Ribeiro, I. A.; Caetano, Liliana Aranha; Gonçalves, Lídia M.; Bettencourt, Ana F.Bone infection (osteomyelitis): burden as a clinical complication of orthopedic surgeries. Controlled antimicrobial release systems: treat and prevent osteomyelitis. Biomaterials based on porous scaffolds: local administration of high concentration of drugs; no systemic toxicity; extended time. Scaffolds in bone tissue engineering: a combination of bioresorbable polymers with bioactive bioglasses; present biodegradability and biosafety; suitable microenvironment and structure; favor osteogenic differentiation and cell growth. Co-encapsulation of drugs: advantageous means for administration of drugs; novel strategy directed to the co-delivery of two antimicrobials (voriconazole and minocycline).
- Release kinetic model and antimicrobial activity of an innovative minocycline and voriconazole co-delivery systemPublication . Zegre, Miguel; Henriques, M.; Ribeiro, I. A.; Caetano, Liliana Aranha; Gonçalves, Lídia M.; Bettencourt, Ana F.Purpose and Strategy: Development of a new local drug-delivery system aiming at bone infection and the modulation of the polymicrobial activity; simultaneous delivery of minocycline and voriconazole, antibacterial and antifungal agents, respectively; polylactide (PDLLA) scaffolds functionalized with collagen and bioglass, osteogenic enhancers.