Browsing by Author "Anbu, Sellamuthu"
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- Catalytic activity of a benzoyl hydrazone based dimeric dicopper(II) complex in catechol and alcohol oxidation reactionsPublication . Anbu, Sellamuthu; Alegria, Elisabete; Pombeiro, ArmandoThe benzoyl hydrazone based dimeric dicopper(II) complex [Cu2(R)(CH3O)(NO3)]2(CH3O)2 (R-Cu2+), recently reported by us, catalyzes the aerobic oxidation of catechols (catechol (S1), 3,5- itertiarybutylcatechol (S2) and 3-nitrocatechol (S3)) to the corresponding quinones (catecholase like activity), as shown by UV–Vis absorption spectroscopy in methanol/HEPES buffer (pH 8.2) medium at 25 C. The highest activity is observed for the substituted catechol (S2) with the electron donor tertiary butyl group, resulting in a turnover frequency (TOF) value of 1.13 103 h1. The complex R-Cu2+ also exhibits a good catalytic activity in the oxidation (without added solvent) of 1-phenylethanol to acetophenone by But OOH under low power (10 W) microwave (MW) irradiation. 2014 Elsevier B.V. All rights reserved.
- Effect of 1,10-phenanthroline on DNA binding, DNA cleavage, cytotoxic and lactate dehydrogenase inhibition properties of Robson type macrocyclic dicopper(II) complexPublication . Anbu, Sellamuthu; Killivalavan, Asaithambi; Alegria, Elisabete; Mathan, Ganeshan; Kandaswamy, MuthusamyDNA targeting macrocyclic dicopper(II) complex, [Cu2L(H2O)2](phen)2(ClO4)2 (L = μ-11,23-dimethyl-3,7,15,19-tetraazatricyclo-[19.3.1.19,13,21] he p t a c o s a-1(24), 2, 7, 9, 11, 13(26), 14, 19, 21(25), 22-decaene-25,26-diol) (2), has been synthesized and characterized. This has been synthesized by reacting a Robson type macrocyclic precursor dicopper(II) complex [Cu2L(H2O)2](ClO4)2 (1) and 1,10-phenanthroline in ethanol. Solution ESR, electronic, and ESI-MS spectral studies suggest that 1,10-phenanthroline replaces coordinated water in 1, giving 2. The influence of the phenanthroline on DNA binding, cleavage, and anticancer properties of 2 have been investigated. Complex 2 displays better DNA binding and cleavage than 1. The dicopper(II) complexes 1 and 2 show cytotoxicity in human cervical HeLa cancer cells, giving IC50 values of 79.41 and 15.82 μM, respectively. Antiproliferative properties of 1 and 2 were confirmed by Trypan Blue exclusive assay and lactate dehydrogenase enzyme level in HeLa cancer cell lysate and content media.
- Electrochemical properties of Robson type macrocyclic dicopper(II) complexesPublication . Alegria, Elisabete; Anbu, Sellamuthu; Martins, Luisa; Pombeiro, ArmandoThe redox properties of the 1,10-phenanthroline containing Robson type symmetrical macrocyclic dicopper(II) complex [Cu2L(H2O.phen)2](ClO4)2 1 (L = μ-11,23-dimethyl-3,7,15,19-tetraazatricyclo-[19.3.1.18 19,13,21] he p t a c o s a-1(24) , 2, 7, 9, 11, 13(26), 14, 19, 21(25), 22-decaene-25,26-diolate) and of its dicopper(II) precursor [Cu2L(H2O)2](ClO4)2 2 have been investigated by cyclic voltammetry and controlled potential electrolysis in different organic solvents. They exhibit two consecutive reversible one-electron reductions assigned to the CuIICuII ® CuICuII ® CuICuI cathodic processes. The results suggest that, in solution, phenanthroline does not coordinate to the metal in complex 1, but its H-bonding interaction with the water ligands can be preserved.