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Femtosecond laser microstructured Alumina toughened Zirconia: a new strategy to improve osteogenic differentiation of hMSCs

2018-03-30Journal article Restricted access
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dc.contributor.authorCarvalho, Angela
dc.contributor.authorCangueiro, Liliana
dc.contributor.authorOliveira, Vitor
dc.contributor.authorVilar, Rui
dc.contributor.authorFernandes, Maria Helena
dc.contributor.authorMonteiro, Fernando
dc.date.accessioned2018-03-01T13:54:48Z
dc.date.available2018-03-01T13:54:48Z
dc.date.issued2018-03-30
dc.description.abstractThe use of topographic patterns has been a continuously growing area of research for tissue engineering and it is widely accepted that the surface topography of biomaterials can influence and modulate the initial biological response. Ultrafast lasers are extremely powerful tools to machine and pattern the surface of a wide range of biomaterials, however, only few work has been performed on ceramics with the intent of biomedical applications, and the biological characterization of these structured materials is scarce. In this work, relevance is given to the biological performance of such materials. A femtosecond laser ablation technique was used to modify Alumina toughened Zirconia (ATZ) surface topography, developing surfaces structured at the micro and nanoscale levels (mu ATZ), in a controlled and reproducible manner. Materials characterization was performed before and after laser treatment, and both materials were compared in terms of osteogenic response of human bone marrow derived mesenchymal stem cells cultured under basal conditions, expecting that the micro/nanofeatures will improve the biological response of cells. Cells metabolic activity and proliferation increased with the culture time and surface microtopography modulated cells alignment and guided proliferation. The modified surface, displayed significantly higher expression of osteogenic transcription factors and genes and, additionally, the formation of a mineralized extracellular matrix, when compared to the control surface, i.e. unmodified ATZ.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCARVALHO, Ângela; [et al] – Femtosecond laser microstructured Alumina toughened Zirconia: A new strategy to improve osteogenic differentiation of hMSCs. Applied Surface Science. ISSN 0169-4332. Vol. 435 (2018), pp. 1237-1245pt_PT
dc.identifier.doi10.1016/j.apsusc.2017.11.206pt_PT
dc.identifier.issn0169-4332
dc.identifier.issn1873-5584
dc.identifier.urihttp://hdl.handle.net/10400.21/8176
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationFEDER funds through the Programa Operacional Factores de Competitividade (COMPETE) - POCI/01/0145/FEDER/007265pt_PT
dc.relationALUMINA TOUGHENED ZIRCONIA MICROFABRICATED SURFACES FOR GUIDED TISSUE REGENERATION APPLIED TO CRANIOFACIAL AND DENTAL IMPLANTS
dc.relation.publisherversionhttps://ac.els-cdn.com/S0169433217334992/1-s2.0-S0169433217334992-main.pdf?_tid=spdf-27f4a5bd-692f-4eff-9400-98c574db9709&acdnat=1519912363_b7c10e33d6dd3fab2cd6304538e17f6dpt_PT
dc.subjectMicrostructured biomaterialspt_PT
dc.subjectFemtosecond laserpt_PT
dc.subjectSurface topographypt_PT
dc.subjectOsteogenic differentiationpt_PT
dc.titleFemtosecond laser microstructured Alumina toughened Zirconia: a new strategy to improve osteogenic differentiation of hMSCspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleALUMINA TOUGHENED ZIRCONIA MICROFABRICATED SURFACES FOR GUIDED TISSUE REGENERATION APPLIED TO CRANIOFACIAL AND DENTAL IMPLANTS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F87624%2F2012/PT
oaire.citation.endPage1245pt_PT
oaire.citation.startPage1237pt_PT
oaire.citation.titleApplied Surface Sciencept_PT
oaire.citation.volume435pt_PT
oaire.fundingStream5876
person.familyNameCarvalho
person.familyNameCangueiro
person.familyNameOliveira
person.familyNameFernandes
person.familyNameMonteiro
person.givenNameAngela
person.givenNameLiliana
person.givenNameVitor
person.givenNameMaria Helena
person.givenNameFernando
person.identifier3312048
person.identifier.ciencia-idDB1F-D036-FFF5
person.identifier.ciencia-idDA1C-25BD-5974
person.identifier.ciencia-idF31D-951A-CA5A
person.identifier.ciencia-id5B1E-8842-AD62
person.identifier.orcid0000-0002-4837-6539
person.identifier.orcid0000-0003-2499-5666
person.identifier.orcid0000-0002-1757-4524
person.identifier.orcid0000-0001-9391-9574
person.identifier.orcid0000-0002-1361-4605
person.identifier.ridL-3224-2014
person.identifier.ridA-3058-2009
person.identifier.ridK-6917-2014
person.identifier.scopus-author-id55851941060
person.identifier.scopus-author-id7006105706
person.identifier.scopus-author-id7202947611
person.identifier.scopus-author-id7006030702
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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