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Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands

2010Journal article Open access
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dc.contributor.authorMoreno, Virtudes
dc.contributor.authorJulia Lorenzo
dc.contributor.authorAviles, Francesc X.
dc.contributor.authorGarcia, M. Helena
dc.contributor.authorRibeiro, João P.
dc.contributor.authorMorais, Tânia S.
dc.contributor.authorFlorindo, Pedro
dc.contributor.authorRobalo, Maria Paula
dc.date.accessioned2011-11-24T16:30:30Z
dc.date.available2011-11-24T16:30:30Z
dc.date.issued2010
dc.description.abstractFour cationic ruthenium(II) complexes with the formula [Ru(eta(5)-C5H5)(PPh3)(2)](+), with L = 5-phenyl-1H-tetrazole (TzH) 1, imidazole (ImH) 2, benzo[1,2-b; 4,3-b'] dithio-phen-2-carbonitrile (Bzt) 3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt) 4 were prepared and characterized in view to evaluate their potentialities as antitumor agents. Studies by Circular Dichroism indicated changes in the secondary structure of ct-DNA. Changes in the tertiary structure of pBR322 plasmid DNA were also observed in gel electrophoresis experiment and the images obtained by atomic force microscopy (AFM) suggest strong interaction with pBR322 plasmid DNA; the observed decreasing of the viscosity with time indicates that the complexes do not intercalate between DNA base pairs. Compounds 1, 2, and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells).por
dc.identifier.citationMoreno V, Lorenzo J, Aviles F X, Garcia M H, Ribeiro J P, Morais T S, Florindo P, Robalo M P.Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands. Bioinorganic Chemistry and Applications. 2010: Art. No. 936834.por
dc.identifier.issn1565-3633
dc.identifier.urihttp://hdl.handle.net/10400.21/554
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherHINDAWI PUBLISHING CORPORATIONpor
dc.relation.ispartofseries;936834
dc.subjectCancer- cell-growthpor
dc.subjectStructural-characterizationpor
dc.subjectOrganometallic chemistrypor
dc.subjectAnticancer activitypor
dc.subjectArene complexespor
dc.subjectAgentspor
dc.subjectDerivativespor
dc.subjectInhibitionpor
dc.subjectApoptosispor
dc.subjectAssaypor
dc.titleStudies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligandspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Yorkpor
oaire.citation.titleBioinorganic Chemistry and Applicationspor
person.familyNameLorenzo
person.familyNameAnselmo Viegas Garcia
person.familyNameRobalo
person.givenNameJulia
person.givenNameMaria Helena
person.givenNameMaria Paula
person.identifier111223
person.identifierH-2175-­2013
person.identifier.ciencia-id0513-9D07-9012
person.identifier.ciencia-id5414-9AEF-4194
person.identifier.ciencia-idE11C-A704-9C18
person.identifier.orcid0000-0001-5659-6008
person.identifier.orcid0000-0002-4344-2218
person.identifier.orcid0000-0002-8200-6910
person.identifier.ridE-9015-2011
person.identifier.ridB-2002-2012
person.identifier.scopus-author-id9233760700
person.identifier.scopus-author-id6507884466
person.identifier.scopus-author-id9269662100
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication71e6cef1-d7d2-4560-81d5-22a7c783a755
relation.isAuthorOfPublicationddef2398-fb7d-4551-a9fe-71c411d1d706
relation.isAuthorOfPublication823a9498-17ab-451f-bb8f-56338643ac0c
relation.isAuthorOfPublication.latestForDiscovery71e6cef1-d7d2-4560-81d5-22a7c783a755

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