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Bioactivities of decoctions from Plectranthus species related to their traditional use on the treatment of digestive problems and alcohol intoxication

2018-06-28Journal article Restricted access
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dc.contributor.authorBrito, Elsa
dc.contributor.authorGomes, Emma
dc.contributor.authorFale, Pedro
dc.contributor.authorBorges, Carlos
dc.contributor.authorPacheco, Rita
dc.contributor.authorTeixeira, Vítor
dc.contributor.authorMachuqueiro, Miguel
dc.contributor.authorAscensão, Lia
dc.contributor.authorSerralheiro, Maria Luisa
dc.date.accessioned2018-11-29T14:50:53Z
dc.date.available2018-11-29T14:50:53Z
dc.date.issued2018-06-28
dc.description.abstractEthnopharmacological relevance Decoctions of Plectranthus species are traditionally ingested after large meals for treatment of food digestion and alcohol abuse. Aim of the study This study aims at associating the digestion-related ethno-uses of Plectranthus species decoctions to molecular mechanism that might explain them: easing digestion (AChE inhibition) and treating hangover (ADH inhibition) Material and methods Decoctions from Plectranthus species were analysed for their alcohol dehydrogenase (ADH) inhibition and acetylcholinesterase (AChE) inhibition, related with alcohol metabolism and intestinal motility, respectively. Identification of the active components was carried out by LC-MS/MS and the docking studies were performed with AChE and the bioactive molecules detected. Results All decoctions inhibited ADH activity. This inhibition was correlated with their rosmarinic acid (RA) content, which showed an IC50 value of 19 μg/mL, similar to the reference inhibitor CuCl2. The presence of RA also leads to most decoctions showing AChE inhibiting capacity. P. zuluensis decoction with an IC50 of 80 μg/mL presented also medioresinol, an even better inhibitor of AChE, as indicated by molecular docking studies. Furthermore, all decoctions tested showed no toxicity towards two human cell lines, and a high capacity to quench free radicals (DPPH), which also play a helpful in the digestive process, related with their RA content. Conclusions All activities presented by the RA-rich Plectranthus decoctions support their use in treating digestion disorders and P. barbatus could explain its use also for alleviating hangover symptoms. Medioresinol, which is present in P. zuluensis, exhibited a significant AChE inhibition and may provide, in the future, a new lead for bioactive compounds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBRITO, Elsa; [et al] – Bioactivities of decoctions from Plectranthus species related to their traditional use on the treatment of digestive problems and alcohol intoxication. Journal of Ethnopharmacology. ISSN 0378-8741. Vol. 220 (2018), pp. 147-154pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.jep.2018.04.006pt_PT
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/10400.21/9111
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPEst-UID/AMB/50017/2013pt_PT
dc.relationDesenvolvimento de um novo campo de forças para lípidos baseado no GROMOS 54A7
dc.relation.publisherversionhttps://reader.elsevier.com/reader/sd/pii/S0378874117344161?token=5BC5684E5FF9B2E33B971F016EF5E1D3F853823227803C01133386FAA777C90A400B03F0B5DBB07AFFBF7F982518F987pt_PT
dc.subjectPlectranthuspt_PT
dc.subjectMedioresinolpt_PT
dc.subjectRosmarinic acidpt_PT
dc.subjectÁcido Rosmarínicopt_PT
dc.subjectEstudos de Dockingpt_PT
dc.titleBioactivities of decoctions from Plectranthus species related to their traditional use on the treatment of digestive problems and alcohol intoxicationpt_PT
dc.typejournal article
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oaire.awardTitleDesenvolvimento de um novo campo de forças para lípidos baseado no GROMOS 54A7
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oaire.citation.endPage154pt_PT
oaire.citation.startPage147pt_PT
oaire.citation.titleJournal of Ethnopharmacologypt_PT
oaire.citation.volume220pt_PT
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person.familyNameBrito
person.familyNameFale
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person.givenNameElsa
person.givenNamePedro
person.givenNameRita
person.givenNameMiguel
person.givenNameLia
person.givenNameMaria Luisa
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