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The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds

2015-09Journal article Restricted access
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dc.contributor.authorCôrte-Real, Leonor
dc.contributor.authorRobalo, Maria Paula
dc.contributor.authorMarques, Fernanda
dc.contributor.authorNogueira, Guilherme
dc.contributor.authorAvecilla, Fernando
dc.contributor.authorSilva, Tiago J.L.
dc.contributor.authorSantos, Filipa C.
dc.contributor.authorTomaz, A. Isabel
dc.contributor.authorGarcia, M. Helena
dc.contributor.authorValente, Andreia
dc.date.accessioned2016-03-14T14:45:26Z
dc.date.available2016-03-14T14:45:26Z
dc.date.issued2015-09
dc.description.abstractA new family of eight ruthenium(II)-cyclopentadienyl bipyridine derivatives, bearing nitrogen, sulfur, phosphorous and carbonyl sigma bonded coligands, has been synthesized. Compounds bearing nitrogen bonded coligands were found to be unstable in aqueous solution, while the others presented appropriate stabilities for the biologic assays and pursued for determination of IC50 values in ovarian (A2780) and breast (MCF7 and MDAMB231) human cancer cell lines. These studies were also carried out for the [5: HSA] and [6: HSA] adducts (HSA = human serum albumin) and a better performance was found for the first case. Spectroscopic, electrochemical studies by cyclic voltammetry and density functional theory calculations allowed us to get some understanding on the electronic flow directions within the molecules and to find a possible clue concerning the structural features of coligands that can activate bipyridyl ligands toward an increased cytotoxic effect. X-ray structure analysis of compound [Ru(eta(5)-C5H5)(bipy)(PPh3)][PF6] (7; bipy = bipyridine) showed crystallization on C2/c space group with two enantiomers of the [Ru(eta(5)-C5H5)(bipy)(PPh3)](+) cation complex in the racemic crystal packing. (C) 2015 Elsevier Inc All rights reserved.pt_PT
dc.identifier.citationCÔRTE-REAL, Leonor; [et al.] - The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds. Journal of Inorganic Biochemistry. ISSN. 0162-0134. Vol. 150 (2015) pp. 148-159pt_PT
dc.identifier.doi10.1016/j.jinorgbio.2015.06.015pt_PT
dc.identifier.issn0162-0134
dc.identifier.issn1873-3344
dc.identifier.urihttp://hdl.handle.net/10400.21/5854
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherELSEVIER SCIENCE INCpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0162013415300209pt_PT
dc.subjectRuthenium(II)pt_PT
dc.subjectCyclopentadienylpt_PT
dc.subjectCyclic voltammetrypt_PT
dc.subjectElectronic flowpt_PT
dc.subjectCytotoxicitypt_PT
dc.titleThe key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compoundspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage159pt_PT
oaire.citation.startPage148pt_PT
oaire.citation.volume150pt_PT
person.familyNameCôrte-Real
person.familyNameRobalo
person.familyNameAnselmo Viegas Garcia
person.givenNameLeonor
person.givenNameMaria Paula
person.givenNameMaria Helena
person.identifierH-2175-­2013
person.identifier.ciencia-idF112-59D7-0984
person.identifier.ciencia-idE11C-A704-9C18
person.identifier.ciencia-id5414-9AEF-4194
person.identifier.orcid0000-0002-4974-1075
person.identifier.orcid0000-0002-8200-6910
person.identifier.orcid0000-0002-4344-2218
person.identifier.ridH-5636-2013
person.identifier.ridB-2002-2012
person.identifier.scopus-author-id55627880500
person.identifier.scopus-author-id9269662100
person.identifier.scopus-author-id6507884466
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf28f9ab9-bbe1-4a86-8a25-3a24538cecec
relation.isAuthorOfPublication823a9498-17ab-451f-bb8f-56338643ac0c
relation.isAuthorOfPublicationddef2398-fb7d-4551-a9fe-71c411d1d706
relation.isAuthorOfPublication.latestForDiscovery823a9498-17ab-451f-bb8f-56338643ac0c

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