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The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity

2020-07-29Journal article Open access
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dc.contributor.authorAraújo-Martins, José
dc.contributor.authorBrás-Geraldes, Carlos
dc.contributor.authorNeuparth, Nuno
dc.date.accessioned2021-01-21T10:26:02Z
dc.date.available2021-01-21T10:26:02Z
dc.date.issued2020-07-29
dc.description.abstractAlthough the pathophysiology of nasal polyposis is incompletely understood, rhinologists have seldom studied it with rhinomanometry or peak nasal inspiratory flow (PNIF) due to technical limitations and the perception that polyp size might impair reproducibility and the usefulness of recordings. The objective of this study is to assess how measures of rhinomanometry and PNIF relate to disease activity. Nineteen patients with polyps, 15 patients with chronic sinusitis without polyps and 11 negative controls were evaluated with active anterior rhinomanometry and PNIF. Sinusitis and polyp patients were re-evaluated after medical treatment. Polyp patients had the highest median Lund-Mackay score (14) and a median Johansen score of 1. PNIF and its variation after treatment were also lowest in this group (median 90 L/min before and after treatment; median variation of 0 L/min). Nasal resistance was similar between groups, and only correlated with Johansen score (Spearman=0.517, p=0.048) after treatment. Our study suggests that evaluating polyp patients using rhinomanometry and PNIF may provide useful and reproducible data. Several findings considered together suggest that polyp size is not the main determinant of nasal functional changes in these patients, warranting further studies to verify whether PNIF changes reflect sinus inflammation or merely airway obstruction.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMARTINS, José Araújo; GERALDES, Carlos Brás; NEUPARTH, Nuno – The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity. Scientific Reports. ISSN 2045-2322. Vol. 10, N.º 1 (2020), pp. 1-9pt_PT
dc.identifier.doi10.1038/s41598-020-69693-6pt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.21/12659
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-020-69693-6.pdfpt_PT
dc.subjectRhinomanometrypt_PT
dc.subjectPeak nasal inspiratory flow (PNIF)pt_PT
dc.subjectChronic sinusitispt_PT
dc.subjectPolyp patientspt_PT
dc.titleThe potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume10pt_PT
person.familyNameAraujo-Martins
person.familyNameBrás-Geraldes
person.familyNameBarreiros Neuparth
person.givenNameJose
person.givenNameCarlos
person.givenNameNuno Manuel
person.identifierhttps://scholar.google.com/citations?hl=pt-PT&user=RqHiu7kAAAAJ
person.identifier.ciencia-id081A-ABD6-13DD
person.identifier.ciencia-idBE1F-5210-2CD9
person.identifier.orcid0000-0002-3950-2716
person.identifier.orcid0000-0002-1551-6531
person.identifier.orcid0000-0001-5149-7473
person.identifier.ridA-4358-2019
person.identifier.scopus-author-id54960937100
person.identifier.scopus-author-id57197972944
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2fa67610-3e88-4d00-8a0b-eb01f6bab93a
relation.isAuthorOfPublication2e79cc97-7263-448f-b230-3bdc4ebefa9b
relation.isAuthorOfPublication6c3850bf-3f11-4b6b-8a89-f607f0fe9894
relation.isAuthorOfPublication.latestForDiscovery2fa67610-3e88-4d00-8a0b-eb01f6bab93a

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