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Proteomics for Biomarker Discovery for Diagnosis and Prognosis of Kidney Transplantation Rejection

2022Journal article Open access
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dc.contributor.authorRamalhete, Luís
dc.contributor.authorAraújo, Rúben
dc.contributor.authorFerreira, Aníbal
dc.contributor.authorCalado, Cecília
dc.date.accessioned2024-03-22T17:38:46Z
dc.date.available2024-03-22T17:38:46Z
dc.date.issued2022
dc.description.abstractRenal transplantation is currently the treatment of choice for end-stage kidney disease, enabling a quality of life superior to dialysis. Despite this, all transplanted patients are at risk of allograft rejection processes. The gold-standard diagnosis of graft rejection, based on histological analysis of kidney biopsy, is prone to sampling errors and carries high costs and risks associated with such invasive procedures. Furthermore, the routine clinical monitoring, based on urine volume, proteinuria, and serum creatinine, usually only detects alterations after graft histologic damage and does not differentiate between the diverse etiologies. Therefore, there is an urgent need for new biomarkers enabling to predict, with high sensitivity and specificity, the rejection processes and the underlying mechanisms obtained from minimally invasive procedures to be implemented in routine clinical surveillance. These new biomarkers should also detect the rejection processes as early as possible, ideally before the 78 clinical outputs, while enabling balanced immunotherapy in order to minimize rejections and reducing the high toxicities associated with these drugs. Proteomics of biofluids, collected through non-invasive or minimally invasive analysis, e.g., blood or urine, present inherent characteristics that may provide biomarker candidates. The current manuscript reviews biofluids proteomics toward biomarkers discovery that specifically identify subclinical, acute, and chronic immune rejection processes while allowing for the discrimination between cell-mediated or antibody-mediated processes. In time, these biomarkers will lead to patient risk stratification, monitoring, and personalized and more efficient immunotherapies toward higher graft survival and patient quality of life.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRamalhete LM, Araújo R, Ferreira A, Calado CRC. Proteomics for Biomarker Discovery for Diagnosis and Prognosis of Kidney Transplantation Rejection. Proteomes. 2022; 10(3):24. https://doi.org/10.3390/proteomes1003002pt_PT
dc.identifier.doihttps://doi.org/10.3390/proteomes10030024pt_PT
dc.identifier.issn2227-7382
dc.identifier.urihttp://hdl.handle.net/10400.21/17205
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2227-7382/10/3/24pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectkidney allograftpt_PT
dc.subjectproteomicspt_PT
dc.subjectbiomarkerpt_PT
dc.subjectrejectionpt_PT
dc.subjectbiofluidspt_PT
dc.subjectexosomespt_PT
dc.titleProteomics for Biomarker Discovery for Diagnosis and Prognosis of Kidney Transplantation Rejectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage17pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleProteomespt_PT
person.familyNameRamalhete
person.familyNameAraújo
person.familyNameAntunes Ferreira
person.familyNameCalado
person.givenNameLuís
person.givenNameRúben Alexandre Dinis
person.givenNameManuel Aníbal
person.givenNameCecília
person.identifier2296066
person.identifier130332
person.identifier.ciencia-idDF19-022D-AA10
person.identifier.ciencia-id9A18-BFDC-ED95
person.identifier.ciencia-id2E10-C387-4982
person.identifier.ciencia-id9418-E320-3177
person.identifier.orcid0000-0002-8911-3380
person.identifier.orcid0000-0002-9369-6486
person.identifier.orcid0000-0002-3300-6033
person.identifier.orcid0000-0002-5264-9755
person.identifier.ridE-2102-2014
person.identifier.scopus-author-id57208672678
person.identifier.scopus-author-id6603163260
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7846e088-851e-47b6-a7bd-d02c9d8f047d
relation.isAuthorOfPublication9998e940-5e65-4661-8308-afcb56d5df01
relation.isAuthorOfPublication14da9d0c-6486-42be-be91-5fc6a965533f
relation.isAuthorOfPublicatione8577257-c64c-4481-9b2b-940fedb360cc
relation.isAuthorOfPublication.latestForDiscoverye8577257-c64c-4481-9b2b-940fedb360cc

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