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Gold nanoparticles functionalized with antibodies: a colorimetric analysis for implementation in PoC devices

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datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
dc.contributor.authorSerafinelli, Caterina
dc.contributor.authorFantoni, Alessandro
dc.contributor.authorAlegria, Elisabete C.B.A.
dc.contributor.authorPacheco, Rita
dc.contributor.authorVieira, Manuela
dc.contributor.authorFantoni, Alessandro
dc.contributor.authorAlegria, Elisabete
dc.contributor.authorPacheco, Rita
dc.contributor.authorVieira, Manuela
dc.date.accessioned2026-09-22T14:50:01Z
dc.date.available2026-09-22T14:50:01Z
dc.date.issued2025
dc.description.abstractThe growing interest in the fast and easy identification of many biomarkers for several diseases, supporting a future precision medicine, results in the development of miniaturized, user-friendly, automated, and portable sensing systems able to provide a real-time and reliable response. Herein we evaluate the sensing capability of gold nanoflowers (AuNFs) for their integration in the setup of the Color Picker System, a Point-of-Care (PoC) sensing device developed by our group for a user-friendly colorimetric detection of molecules. A simulation study measures the color changes arising from the variations in the dielectric environment around the AuNFs surface. The process starts with the synthesis of AuNFs and their functionalization with 3-Mercaptopropionic acid. The measured transmittance spectra of the AuNFs before and after the functionalization, have been combined with the spectra of two different light sources to simulate the spectral response of the light transmitted through the colloidal dispersion. The calculated spectra have been converted into vectors in different color spaces producing the color chart. The sensitivity of the AuNFs has been evaluated as Euclidian distance between two consecutive points in the color chart, but also as differences in the RGB channels, that are the one returned from the Color Picker System. The AuNFs showed the greatest distances in the color chart and the greatest differences in the RGB when using the Cold LED as light source. The chromatic changes arising from their use make the AuNFs a potential sensing platform to be inserted into the Color Picker System for antibodies sensing. © 2025 SPIE.eng
dc.description.sponsorshipIPL/IDI&CA2023/LUMINA
dc.description.sponsorshipLA/P/0056/2020
dc.identifier.citationSerafinelli, C., Fantoni, A., Alegria, E. C. B. A., Pacheco, R., & Vieira, M. (2025). Gold nanoparticles functionalized with antibodies: A colorimetric analysis for implementation in PoC devices. In Proceedings of SPIE 13336, Colloidal Nanoparticles for Biomedical Applications XX (Article 133360B). SPIE. https://doi.org/10.1117/12.3042427
dc.identifier.doi10.1117/12.3042427
dc.identifier.isbn978-151068420-1
dc.identifier.issn16057422
dc.identifier.urihttp://hdl.handle.net/10400.21/23176
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSPIE
dc.relationCentre of Technology and Systems
dc.relationCentro de Química Estrutural
dc.relation.hasversionhttps://www.spiedigitallibrary.org/conference-proceedings-of-spie/13336/3042427/Gold-nanoparticles-functionalized-with-antibodies--a-colorimetric-analysis-for/10.1117/12.3042427.full
dc.rights.uriN/A
dc.subjectAuNFs
dc.subjectColorimetric detection
dc.subjectPoC Device
dc.subjectPrecision medicine
dc.titleGold nanoparticles functionalized with antibodies: a colorimetric analysis for implementation in PoC deviceseng
dc.typeconference paper
dspace.entity.typePublication
oaire.awardNumberUIDB/00066/2020
oaire.awardNumberUIDB/00100/2020
oaire.awardTitleCentre of Technology and Systems
oaire.awardTitleCentro de Química Estrutural
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00066%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT
oaire.citation.conferenceDate2025
oaire.citation.conferencePlaceSan Francisco
oaire.citation.issue133360B
oaire.citation.titleProceedings of SPIE
oaire.citation.volume13336
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFantoni
person.familyNameAlegria
person.familyNamePacheco
person.familyNameVieira
person.givenNameAlessandro
person.givenNameElisabete
person.givenNameRita
person.givenNameManuela
person.identifier863202
person.identifier1022927
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person.identifier.ciencia-id8C1F-851A-9F1C
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person.identifier.ciencia-id9516-E25E-BB8E
person.identifier.orcid0000-0002-9938-0351
person.identifier.orcid0000-0003-4060-1057
person.identifier.orcid0000-0001-5192-3006
person.identifier.orcid0000-0002-1150-9895
person.identifier.ridK-1105-2016
person.identifier.ridE-9945-2012
person.identifier.ridC-3062-2012
person.identifier.ridV-7860-2017
person.identifier.scopus-author-id7006535604
person.identifier.scopus-author-id8315848300
person.identifier.scopus-author-id8853708300
person.identifier.scopus-author-id7202140173
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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ISEL - Eng. Quim. Biol. - Comunicações