Repository logo
 
Publication

Avoiding healthy cells extinction in a cancer model

2014-05-21Journal article Restricted access
Simple item page
dc.contributor.authorLopez, Álvaro G.
dc.contributor.authorSabuco, Juan
dc.contributor.authorSeoane, Jesus M.
dc.contributor.authorDuarte, Jorge
dc.contributor.authorJanuário, Cristina
dc.contributor.authorSanjuan, Miguel A. F.
dc.date.accessioned2015-08-25T13:37:52Z
dc.date.available2015-08-25T13:37:52Z
dc.date.issued2014-05-21
dc.description.abstractWe consider a dynamical model of cancer growth including three interacting cell populations of tumor cells, healthy host cells and immune effector cells. For certain parameter choice, the dynamical system displays chaotic motion and by decreasing the response of the immune system to the tumor cells, a boundary crisis leading to transient chaotic dynamics is observed. This means that the system behaves chaotically for a finite amount of time until the unavoidable extinction of the healthy and immune cell populations occurs. Our main goal here is to apply a control method to avoid extinction. For that purpose, we apply the partial control method, which aims to control transient chaotic dynamics in the presence of external disturbances. As a result, we have succeeded to avoid the uncontrolled growth of tumor cells and the extinction of healthy tissue. The possibility of using this method compared to the frequently used therapies is discussed. (C) 2014 Elsevier Ltd. All rights reserved.por
dc.identifier.citationÁlvaro G.; [et al] – Avoiding healthy cells extinction in a cancer model. Journal of Theoretical Biology. ISSN: 0022-5193. Vol. 349 (2014), pp. 74-81por
dc.identifier.doi10.1016/j.jtbi.2014.01.040
dc.identifier.issn0022-5193
dc.identifier.issn1095-8541
dc.identifier.urihttp://hdl.handle.net/10400.21/5000
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAcademic Press LTD – Elsevier Science LTDpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0022519314000599#
dc.subjectCancer Modelspor
dc.subjectPartial Controlpor
dc.subjectChaospor
dc.subjectTumor Growthpor
dc.subjectTherapypor
dc.titleAvoiding healthy cells extinction in a cancer modelpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage81por
oaire.citation.startPage74por
oaire.citation.titleJournal of Theoretical Biologypor
oaire.citation.volume349por
person.familyNameDuarte
person.givenNameJorge
person.identifier.ciencia-idBC1D-1E83-E2B2
person.identifier.orcid0000-0003-2641-3199
person.identifier.ridG-7261-2011
person.identifier.scopus-author-id35310049800
rcaap.rightsclosedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4dbec82a-caa4-4662-b156-af73687e867f
relation.isAuthorOfPublication.latestForDiscovery4dbec82a-caa4-4662-b156-af73687e867f

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
AVOIDING HEALTHY CELLS EXTINCTION IN A CANCER MODEL.pdf
Size:
1.82 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ISEL - Matemática - Artigos