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Syntheses, molecular structures, electrochemical behavior, theoretical study, and antitumor activities of organotin(IV) complexes containing 1-(4-chlorophenyl)-1-cyclopentanecarboxylato ligands

2011-09-05Journal article Open access
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dc.contributor.authorShang, Xianmei
dc.contributor.authorMeng, Xianggao
dc.contributor.authorAlegria, Elisabete
dc.contributor.authorLi, Qingshan
dc.contributor.authorGuedes Da Silva, M. Fátima C.
dc.contributor.authorKuznetsov, Maxim L.
dc.contributor.authorPombeiro, Armando
dc.date.accessioned2013-02-17T13:00:53Z
dc.date.available2013-02-17T13:00:53Z
dc.date.issued2011-09-05
dc.description.abstractThe organotin(IV) compounds [Me2Sn(L)(2)] (1), [Et(2)sn(L)(2)] (2), [(Bu2Sn)-Bu-n(L)(2)] (3), [(n)Oct(2)Sn(L)(2)] (4), [Ph2Sn(L)(2)] (5), and [PhOSnL](6) (6) have been synthesized from the reactions of 1-(4-chlorophenyl)-1-cyclopentanecarboxylic acid (HL) with the corresponding diorganotin(IV) oxide or dichloride. They were characterized by IR and multinuclear NMR spectroscopies, elemental analysis, cyclic voltammetry, and, for 2, 3, 4 and 6, single crystal X-ray diffraction analysis. While 1-5 are mononuclear diorganotin (IV) compounds, the X-ray diffraction of 6 discloses a hexameric drumlike structure with a prismatic Sn6O6 core. All these complexes undergo irreversible reductions and were screened for their in vitro antitumor activities toward HL-60, BGC-823, Bel-7402, and KB human cancer cell lines. Within the mononuclear compounds, the most active ones (3, 5) are easiest to reduce (least cathodic reduction potentials), while the least active ones (1, 4) are the most difficult to reduce. Structural rearrangements (i.e., Sn-O bond cleavages and trans-to-cis isomerization) induced by reduction, which eventually can favor the bioactivity, are disclosed by theoretical/electrochemical studies.por
dc.identifier.citationSHANG, Xianmei; MENG, Xianggao; ALEGRIA, Elisabete C. B. A.; LI, Qingshan; GUEDES DA SILVA, M. Fátima C.; KUZNETSOV, Maxim L.; POMBEIRO, Armando J. L. - Syntheses, molecular structures, electrochemical behavior, theoretical study, and antitumor activities of organotin(IV) complexes containing 1-(4-Chlorophenyl)-1-cyclopentanecarboxylato ligands. Renewable Energy. ISSN 0020-1669. Vol. 50, n.º 17 (2011) p. 8158-8167.por
dc.identifier.issn0020-1669
dc.identifier.urihttp://hdl.handle.net/10400.21/2250
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAmer Chemical SOCpor
dc.subjectRedox propertiespor
dc.subjectDiorganotin(IV) complexespor
dc.subjectOrganometallic chemistrypor
dc.subjectCoordinatio-compoundspor
dc.subjectAnticancer complexespor
dc.subjectCancer-chemotherapypor
dc.subjectRuthenium complexespor
dc.subjectCrystal-structurespor
dc.subjectCell-growthpor
dc.subjectNMR-spectrapor
dc.titleSyntheses, molecular structures, electrochemical behavior, theoretical study, and antitumor activities of organotin(IV) complexes containing 1-(4-chlorophenyl)-1-cyclopentanecarboxylato ligandspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceWashingtonpor
oaire.citation.endPage8167por
oaire.citation.issue17por
oaire.citation.startPage8158por
oaire.citation.titleRenewable Energypor
oaire.citation.volume50por
person.familyNameShang
person.familyNameAlegria
person.familyNameGuedes da Silva
person.familyNameKuznetsov
person.familyNamePombeiro
person.givenNameXianmei
person.givenNameElisabete
person.givenNameM. Fátima C.
person.givenNameMaxim L.
person.givenNameArmando
person.identifier863202
person.identifier789079
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person.identifier.ciencia-id7619-8E8E-979A
person.identifier.ciencia-id7018-EEFE-E023
person.identifier.ciencia-id8311-38FA-CEFB
person.identifier.orcid0000-0002-8616-2419
person.identifier.orcid0000-0003-4060-1057
person.identifier.orcid0000-0003-4836-2409
person.identifier.orcid0000-0001-5729-6189
person.identifier.orcid0000-0001-8323-888X
person.identifier.ridE-9945-2012
person.identifier.ridH-8274-2012
person.identifier.ridH-7934-2012
person.identifier.ridI-5945-2012
person.identifier.scopus-author-id8315848300
person.identifier.scopus-author-id6701761571
person.identifier.scopus-author-id7102379353
person.identifier.scopus-author-id7006067269
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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